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Organic Chemistry

Working Paper

Site-Specific β-C(sp3)–H Fluorination of N-Substituted Amines: A Late-Stage Functionalization Strategy Enabled by Electrochemistry

Luiz Novaes, Justin Ho, Kaining Mao, Elisia Villemure, Jack Terrett, Song Lin

Version 1 posted 12 January 2024

2,128

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Organic Chemistry

Working Paper

Stereoselective Two-Carbon Ring Expansion of Allylic Amines via Electronic Control of Palladium-Promoted Equilibria

Jonathan Knowles, Charles Mikan, Aidan Matthews, Daniel Harris, Charlotte McIvor, Paul Waddell, Mark Sims

Version 2 posted 24 April 2023

804

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Biological and Medicinal Chemistry

Working Paper

Reversible Small Molecule pan-Ras Inhibitors Display Tunable Affinity for the Active and Inactive forms of Ras.

Charles Parry, Francesca Pellicano, Alexander W. Schüttelkopf, Kim Beyer, Justin Bower, Amy Bryson, Kenneth S. Cameron, Nichole M. Cerutti, Jonathan P. Clark, Stuart Davidson, Keneth Davies, Martin J. Drysdale, Jeffrey Engelman, Anna Estevan-Barber, Andrea Gohlke, Christopher H. Gray, Daniel A. Guthy, Min Hong, Alana Hopkins, Luke Hutchinson, Jennifer Konczal, Michel Maira, Duncan McArthur, Mokdad Mezna, Heather McKinnon, Ridvan Nepravishta, Nils Ostermann, Camila Pasquali, Katie Pollock, Angelo Pugliese, Nicholas Rooney, Niko Schmiedeberg, Paul Shaw, Camilo Velez-Vega, Christopher West, Ryan West, Frederic Zecri, John B. Taylor

Version 2 posted 14 November 2024

1,022

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Biological and Medicinal Chemistry

Working Paper

Assessing the activity of benzodioxol, phenol and aniline derivatives as radical trapping antioxidants that inhibit ferroptosis

Helene B. E. Schricker, Mohamed M. Mouzayek, Jonas Wanninger, Hala Zahran, Kyra Lützel, Anna V. Milton, Eikan Mishima, Toshitaka Nakamura, Bettina Proneth, Marcus Conrad, David B. Konrad

Version 1 posted 28 March 2024

424

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Theoretical and Computational Chemistry

Working Paper

Graph transformer neural network for chemical reactivity prediction

David F. Nippa, Kenneth Atz, Alex T. Müller, Jens Wolfard, Clemens Isert, Martin Binder, Oliver Scheidegger, David B. Konrad, Uwe Grether, Rainer E. Martin, Gisbert Schneider

Version 1 posted 16 May 2023

1,261

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Biological and Medicinal Chemistry

Working Paper

Integration of Computational and Experimental Techniques for the Discovery of SARS-CoV-2 PLpro Covalent Inhibitors

Ho Ying Huang, Sharon Pinus, Xiao Cong Zhang, Guanyu Wang, Andrés M Rueda, Yaouba Souaibou, Solène Huck, Mitchell Huot, Danielle Vlaho, Joshua Pottel, Felipe Venegas, Zhuoqun Lu, Christopher Hennecker, Julia Stille, Jevgenijs Tjutrins, Caitlin Miron, Anne Labarre, Jessica Plescia, Mihai Burai-Patrascu, Anthony Mittermaier, Nicolas Moitessier

Version 1 posted 15 September 2023

321

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Biological and Medicinal Chemistry

Working Paper

Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor

Madeline Hennessy, Anna Gutridge, Alexander French, Elizabeth Rhoda, Yazan Meqbil, Meghna Gill, Yavnika Kashyap, Kevin Appourchaux, Barnali Pauli, Z. Jim Wang, Richard van Rijn, Andrew Riley

Version 2 posted 09 February 2023

1,000

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Organic Chemistry

Review

Decarboxylative Cross-Coupling: A Radical Tool In Medicinal Chemistry

Gabriele Laudadio, Maximilian Palkowitz, Tamara Ewing, Phil Baran

Version 1 posted 20 June 2022

6,104

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Organic Chemistry

Working Paper

Harnessing Diazoketones for the Efficient Synthesis of 2,4-Disubstituted-(1,3)Thiazoles: Scalable and Versatile Approach to Important Heterocyclic Scaffolds

Viacheslav Pendiukh, Hanna Yakovleva, Ivan Stadniy, Olexandr Pashenko, Olesia Volovenko, Alexander Rozhenko, Serhiy Ryabukhin, Dmytro Volochnyuk

Version 1 posted 18 January 2024

294

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Organic Chemistry

Working Paper

Late-Stage C(sp2)–C(sp3) Diversification via Nickel Oxidative Addition Complexes

Ruben Martin, Carlota Odena, Maria Lourdes Linares, Nahury Castellanos-Blanco, Ryan McGuire, Jose Manuel Alonso, Alejandro Dieguez, Eric Tan, Jesus Alcazar, Peter Buijnsters, Santiago Cañellas

Version 1 posted 08 August 2023

1,668

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69 results in medicinal Chemistry in Keywords: medicinal Chemistry

Site-Specific β-C(sp3)–H Fluorination of N-Substituted Amines: A Late-Stage Functionalization Strategy Enabled by Electrochemistry

Stereoselective Two-Carbon Ring Expansion of Allylic Amines via Electronic Control of Palladium-Promoted Equilibria

Reversible Small Molecule pan-Ras Inhibitors Display Tunable Affinity for the Active and Inactive forms of Ras.

Assessing the activity of benzodioxol, phenol and aniline derivatives as radical trapping antioxidants that inhibit ferroptosis

Graph transformer neural network for chemical reactivity prediction

Integration of Computational and Experimental Techniques for the Discovery of SARS-CoV-2 PLpro Covalent Inhibitors

Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor

Decarboxylative Cross-Coupling: A Radical Tool In Medicinal Chemistry

Harnessing Diazoketones for the Efficient Synthesis of 2,4-Disubstituted-(1,3)Thiazoles: Scalable and Versatile Approach to Important Heterocyclic Scaffolds

Late-Stage C(sp2)–C(sp3) Diversification via Nickel Oxidative Addition Complexes

69 results in Keywords: medicinal Chemistry