Organic Chemistry

Putting MicroED to the Test: An Account of the Evaluation of 30 Diverse Pharmaceutical Compounds

Authors

Abstract

The application of microcrystal electron diffraction (microED) to a variety of pharmaceutical compounds is reported. The examples and work detailed showcase the utility of microED as a routine technique for the rapid collection, analysis, and generation of structural data on a number of pharmaceutically relevant compounds, requiring minimal sample preparation and often without the need for time-consuming vitrification and cryo transfer processes. The development of a scripted data processing workflow allowed for simultaneous collection and processing of electron diffraction data, further expediting structural analysis of fifteen compounds.

Content

Thumbnail image of MicroED Manuscript Amgen For Submission.pdf

Supplementary material

Thumbnail image of MicroED SI For Submission.pdf
Supporting Information
Materials and methods, crystal structure data, Python code