Working Paper
Authors
- Jessica E. Burch
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University of California, Los Angeles
, - Austin G. Smith Amgen (United States) ,
- Seb Caille Amgen (United States) ,
- Shawn D. Walker Amgen (United States) ,
- Ryan Wurz Amgen (United States) ,
- Victor J. Cee Amgen (United States) ,
- Jose Rodriguez University of California, Los Angeles ,
- D. Gostovic MicroEDLab ,
- Kyle Quasdorf Amgen (United States) ,
- Hosea M. Nelson University of California, Los Angeles & California Institute of Technology
Abstract
The application of microcrystal electron diffraction (microED) to a variety of pharmaceutical compounds is reported. The examples and work detailed showcase the utility of microED as a routine technique for the rapid collection, analysis, and generation of structural data on a number of pharmaceutically relevant compounds, requiring minimal sample preparation and often without the need for time-consuming vitrification and cryo transfer processes. The development of a scripted data processing workflow allowed for simultaneous collection and processing of electron diffraction data, further expediting structural analysis of fifteen compounds.
Content
Supplementary material
Supporting Information
Materials and methods, crystal structure data, Python code
