Harnessing Diazoketones for the Efficient Synthesis of 2,4-Disubstituted-(1,3)Thiazoles: Scalable and Versatile Approach to Important Heterocyclic Scaffolds

18 January 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


This study presents a scalable one-pot synthesis of 2,4-disubstituted-(1,3)thiazoles using diazoketones with thiosemicarbazide or thiourea, achieving high yields across various substrates. Thiazole derivatives demonstrate diverse biological activities (antibacterial, antiviral, anticancer, etc.) and applications in nanoelectronics and material science The suggested approach to their preparation highlights diazoketones as a chemically resilient alternative to traditionally used halogen ketones. This versatile synthesis method expands the scope of available 2,4-disubstituted-(1,3)thiazoles and opens broad opportunities for this class of compounds to contribute to advancements in medicinal chemistry and technology on the next level.


halogen ketones
medicinal chemistry


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.