The Carbodiimide Click Reaction Provides Rapid and Conver-gent Access to Aminotriazoloquinazolines

A novel, convergent synthesis of aminotriazoloquinazolines is reported. These heterocycles are reliably prepared via a “click” reaction between readily available aryl carbodiimides and acyl hydrazides. Such products are of particular interest with respect to their inhibitory activity against the A2A and A2B adenosine receptors and the title “click” reaction has greatly accelerated the discovery of potent/selective chemical matter in this space.