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10 results in Keywords: Protein degradation

From Inhibition to Degradation: Targeting the Anti-apoptotic Protein Myeloid Cell Leukemia 1(MCL1)

James Papatzimas, Evgueni Gorobets, Ranjan Maity, Mir Ishruna Muniyat, Justin L. MacCallum, Paola Neri, Nizar J. Bahlis, Darren Derksen

Version 1 posted 15 February 2019

1,444

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Biological and Medicinal Chemistry

Working Paper

Optical Control of Small Molecule-Induced Protein Degradation

Yuta Naro, Kristie Darrah, Alexander Deiters

Version 1 posted 03 June 2019

1,293

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Biological and Medicinal Chemistry

Working Paper

A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

Cyrille Kounde, Maria M. Shchepinova, Edward Tate

Version 2 posted 23 December 2019

1,229

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Biological and Medicinal Chemistry

Working Paper

Rational Design and Synthesis of Novel Dual Protacs for Simultaneous Degradation of EGFR and PARP

Mengzhu Zheng, Junfeng Huo, Xiaoxia Gu, Canrong Wu, Qingzhe Zhang, Wang Wang, Yang Liu, Yu Liu, Xuechen Zhou, Lixia Chen, Yirong Zhou, Hua Li

Version 1 posted 18 February 2021

945

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Biological and Medicinal Chemistry

Working Paper

Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype

Gang Xue, Jianing Xie, Matthias Hinterndorfer, Marko Cigler, Hana Imrichova, Soheila Adariani, Lara Dötsch, Georg Winter, Herbert Waldmann

Version 1 posted 10 March 2023

2,052

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Biological and Medicinal Chemistry

Working Paper

Targeted Degradation of Antigen-Specific Pathogenic Autoantibodies That Cause Heart Failure

Edward deRamon, David McDonald, David Spiegel

Version 1 posted 01 March 2024

296

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Biological and Medicinal Chemistry

Working Paper

Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity

Victoria Klein, Adam Bond, Conner Craigon, R. Scott Lokey, Alessio Ciulli

Version 1 posted 05 July 2021

2,276

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Biological and Medicinal Chemistry

Working Paper

Proteolysis-Targeting Chimeras (PROTACs) Based on Macrocyclic Tetrapeptides Selectively Degrade Class I Histone Deacetylases 1–3

Martin Roatsch, Anja Vogelmann, Daniel Herp, Manfred Jung, Christian Adam Olsen

Version 1 posted 04 June 2020

1,731

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Biological and Medicinal Chemistry

Working Paper

Targeted Degradation of Oncogenic KRASG12C by VHL-recruiting PROTACs

Michael J. Bond, Ling Chu, Dhanusha A. Nalawansha, Ke Li, Craig Crews

Version 1 posted 10 April 2020

3,722

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Biological and Medicinal Chemistry

Working Paper

Chemoproteomic mapping of the N-terminal cysteinome

Esben Svenningsen, Fatih Demir, Florian Kromm, Anna Rahimic, David Olagnier, Markus Rinschen, Thomas Poulsen

Version 1 posted 24 September 2024

278

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10 results in Protein degradation in Keywords: Protein degradation

From Inhibition to Degradation: Targeting the Anti-apoptotic Protein Myeloid Cell Leukemia 1(MCL1)

Optical Control of Small Molecule-Induced Protein Degradation

A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

Rational Design and Synthesis of Novel Dual Protacs for Simultaneous Degradation of EGFR and PARP

Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype

Targeted Degradation of Antigen-Specific Pathogenic Autoantibodies That Cause Heart Failure

Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity

Proteolysis-Targeting Chimeras (PROTACs) Based on Macrocyclic Tetrapeptides Selectively Degrade Class I Histone Deacetylases 1–3

Targeted Degradation of Oncogenic KRASG12C by VHL-recruiting PROTACs

Chemoproteomic mapping of the N-terminal cysteinome

10 results in Keywords: Protein degradation