Optical Control of Small Molecule-Induced Protein Degradation

03 June 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


As an emerging approach to protein perturbation, small molecule-induced protein degradation has gained significant attention as both a chemical tool and a potential therapeutic. To enable discreet spatiotemporal control over its activity, we have developed a broadly applicable approach for the optical control of small molecule-induced protein degradation. Installation of photolabile caging groups onto ligands recruiting Von Hippel-Lindau (VHL) and cereblon (CRBN) E3 ubiquitin ligases enabled optical control over protein degradation.


caged small molecule
optical control
protein degradation

Supplementary materials

caged PROTACs SI


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