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16 results in Keywords: Covalent inhibitors

Biological and Medicinal Chemistry

Working Paper

Reactive Docking: a computational method for high-throughput virtual screenings of reactive species

Giulia Bianco, Matthew Holcomb, Diogo Santos-Martins, Andreas Tillack, Althea Hansel-Harris, Stefano Forli

Version 1 posted 19 May 2023

415

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Organic Chemistry

Working Paper

Aryl Fluorosulfate-Based Inhibitors that Covalently Target the SIRT5 Lysine Deacylase

Julie E. Bolding, Pablo Martín-Gago, Nima Rajabi, Luke F. Gamon, Tobias N. Hansen, Michael Jonathan Davies, Christian Adam Olsen

Version 1 posted 23 February 2022

489

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Citations

Biological and Medicinal Chemistry

Working Paper

Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles

Moritz Schwarz, Maksym Kurkunov, Florian Wittlinger, Ramona Rudalska, Guiqun Wang, Martin P. Schwalm, Alexander Rasch, Benedikt Wagner, Stefan A. Laufer, Stefan Knapp, Daniel Dauch, Matthias Gehringer

Version 2 posted 25 March 2024

1,151

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Biological and Medicinal Chemistry

Working Paper

Tunable Cysteine-Targeting Electrophilic Hetero-Aromatic Warheads Induce Ferroptosis

Endri Karaj, Shaimaa H. Sindi, Nishanth Kuganesan, Lalith Perera, William Taylor, L. M. Viranga Tillekeratne

Version 1 posted 11 April 2022

982

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Biological and Medicinal Chemistry

Working Paper

Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor

Ricardo Serafim, André Santiago, Caio dos Reis, Jessica Takarada, Priscila Mezzomo, Katlin Massirer, Martin P. Schwalm, Mark Kudolo, Stefan Gerstenecker, Apirat Chaikuad, Stefan Knapp, Stefan Laufer, Rafael Counago, Matthias Gehringer

Version 1 posted 20 May 2021

957

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Biological and Medicinal Chemistry

Working Paper

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Saleta Vazquez-Rodriguez, Miranda Wright, Catherine Rogers, Adam Cribbs, Srikannathasan Velupillai, Martin Philpott, Henry Lee, James E. Dunford, Kilian Huber, Matthew B. Robers, Jim Vasta, Marie-Laetitia Thezenas, Sarah Bonham, Benedikt M. Kessler, James Bennett, Oleg Fedorov, Florence Raynaud, Adam Donovan, Julian Blagg, Vassilios Bavetsias, Udo Oppermann, Akane Kawamura, Paul Brennan

Version 1 posted 11 September 2018

883

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Citations

Biological and Medicinal Chemistry

Working Paper

Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome

Patrick R. A. Zanon, Lisa Lewald, Stephan M. Hacker

Version 1 posted 20 September 2019

1,135

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Biological and Medicinal Chemistry

Working Paper

Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2)

Stefan Gerstenecker, Lisa Haarer, Martin Schröder, Mark Kudolo, Martin P. Schwalm, Valentin Wydra, Ricardo Serafim, Apirat Chaikuad, Stefan Knapp, Stefan Laufer, Matthias Gehringer

Version 1 posted 15 July 2021

351

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Biological and Medicinal Chemistry

Working Paper

Competitive Profiling of Ligandable Cysteines in Staphylococcus aureus with an Organogold Compound

Claudia Schmidt, Michael Zollo, Riccardo Bonsignore, Angela Casini, Stephan M. Hacker

Version 1 posted 17 February 2022

417

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Biological and Medicinal Chemistry

Working Paper

Rationally Designed Potent BMX Inhibitors Reveals Mode of Covalent Binding at the Atomic Level

João D. Seixas, Bárbara B. Sousa, Marta C. Marques, Ana Guerreiro, Rui Traquete, Tiago Rodrigues, Inês S. Albuquerque, Marcos Sousa, Ana R. Lemos, Pedro M. F. Sousa, Tiago M. Bandeiras, Di Wu, Shelby K. Doyle, Carol V. Robinson, Angela Koehler, Francisco Corzana, Pedro Matias, Gonçalo Bernardes

Version 1 posted 09 January 2020

1,104

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16 results in Covalent inhibitors in Keywords: Covalent inhibitors

Reactive Docking: a computational method for high-throughput virtual screenings of reactive species

Aryl Fluorosulfate-Based Inhibitors that Covalently Target the SIRT5 Lysine Deacylase

Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles

Tunable Cysteine-Targeting Electrophilic Hetero-Aromatic Warheads Induce Ferroptosis

Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome

Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2)

Competitive Profiling of Ligandable Cysteines in Staphylococcus aureus with an Organogold Compound

Rationally Designed Potent BMX Inhibitors Reveals Mode of Covalent Binding at the Atomic Level

16 results in Keywords: Covalent inhibitors