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8 results in Authors: Jacob Bush

Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome

Katharine Gilbert, Aini Vuorinen, Arron Aatkar, Peter Pogany, Jonathan Pettinger, Emma Grant, Joanna Kirkpatrick, Katrin Rittinger, David House, Glenn Burley, Jacob Bush

Version 2 posted 16 February 2022

1,994

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Biological and Medicinal Chemistry

Working Paper

Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation

Adam Thomas, Marta Serafini, Emma Grant, Edward Coombs, Joseph Bluck, Matthias Schiedel, Michael McDonough, Jessica Reynolds, Bernadette Lee, Michael Platt, Vassilena Sharlandjieva, Philip Biggin, Fernanda Duarte, Thomas Milne, Jacob Bush, Stuart Conway

Version 1 posted 25 July 2023

378

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Catalysis

Working Paper

A Chemo- and Regioselective Tandem [3+2]Heteroannulation Strategy for Carbazole Synthesis: Synergizing Two Mechanistically Distinct Bond-Forming Processes

Glenn Burley, Emma Campbell, Andrea Taladriz-Sender, Olivia Paisley, Alan Kennedy, Jacob Bush

Version 1 posted 24 November 2021

327

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Biological and Medicinal Chemistry

Working Paper

Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments

Arron Aatkar, Aini Vuorinen, Oliver Longfield, Katharine Gilbert, Rachel Peltier-Heap, Craig Wagner, Francesca Zappacosta, Katrin Rittinger, Chun-wa Chung, David House, Nicholas Tomkinson, Jacob Bush

Version 2 posted 15 December 2022

1,119

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Organic Chemistry

Working Paper

Automated LC-MS Analysis and Data Extraction for High-Throughput Chemistry

Joseph Mason, Harry Wilders, David J. Fallon, Ross P. Thomas, Jacob T. Bush, Nicholas C. O. Tomkinson, Francesco Rianjongdee

Version 1 posted 25 July 2023

1,048

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Biological and Medicinal Chemistry

Working Paper

PhotoAffinity Bits: A Photoaffinity-Based Fragment Screening Platform for Efficient Identification of Protein Ligands

Emma K. Grant, David J. Fallon, Michael M. Hann, Ken G. M. Fantom, Chad Quinn, Francesca Zappacosta, Roland S. Annan, Chun-wa Chung, Paul Bamborough, David P. Dixon, Peter Stacey, David House, Vipulkumar K. Patel, Nicholas C. O. Tomkinson, Jacob T. Bush

Version 1 posted 01 April 2020

1,318

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Biological and Medicinal Chemistry

Working Paper

Metabolic Engineering Optimizes Bioorthogonal Glycan Labeling in Living Cells

Anna Cioce, Ganka Bineva-Todd, Anthony J. Agbay, Junwon Choi, Thomas M. Wood, Marjoke Debets, William Browne, Holly Douglas, Chloe Roustan, Omur Yilmaz Tastan, Svend Kjaer, Jacob T. Bush, Carolyn Bertozzi, Benjamin Schumann

Version 1 posted 04 January 2021

634

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Citations

Biological and Medicinal Chemistry

Working Paper

A Direct-to-Biology High-Throughput Chemistry Approach to Reactive Fragment Screening

Ross P. Thomas, Rachel E. Heap, Francesca Zappacosta, Emma K. Grant, Peter Pogany, Stephen Besley, David J. Fallon, Michael M. Hann, David House, Nicholas C. O. Tomkinson, Jacob T. Bush

Version 1 posted 24 March 2021

702

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8 results in Jacob Bush in Authors: Jacob Bush

Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome

Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation

A Chemo- and Regioselective Tandem [3+2]Heteroannulation Strategy for Carbazole Synthesis: Synergizing Two Mechanistically Distinct Bond-Forming Processes

Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments

Automated LC-MS Analysis and Data Extraction for High-Throughput Chemistry

PhotoAffinity Bits: A Photoaffinity-Based Fragment Screening Platform for Efficient Identification of Protein Ligands

Metabolic Engineering Optimizes Bioorthogonal Glycan Labeling in Living Cells

A Direct-to-Biology High-Throughput Chemistry Approach to Reactive Fragment Screening

8 results in Authors: Jacob Bush