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9 results in Authors: Daniel Merk

The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Caffeine and Istradefylline

Giuseppe Faudone, Whitney Kilu, Xiaomin Ni, Apirat Chaikuad, Sridhar Sreeramulu, Pascal Heitel, Harald Schwalbe, Stefan Knapp, Manfred Schubert-Zsilavecz, Jan Heering, Daniel Merk

Version 1 posted 10 May 2021

312

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Biological and Medicinal Chemistry

Working Paper

Combining Generative Artificial Intelligence and On-Chip Synthesis for De Novo Drug Design

Francesca Grisoni, Berend Huisman, Alexander Button, Michael Moret, Kenneth Atz, Daniel Merk, Gisbert Schneider

Version 1 posted 30 December 2020

724

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Theoretical and Computational Chemistry

Working Paper

Deep interactome learning for de novo drug design

Kenneth Atz, Leandro Cotos Muñoz, Clemens Isert, Maria Håkansson, Dorota Focht, David F. Nippa, Mattis Hilleke, Michael Iff, Jann Ledergerber, Carl C. G. Schiebroek, Jan A. Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider

Version 1 posted 19 September 2023

1,055

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Biological and Medicinal Chemistry

Working Paper

Structure-guided design of a highly potent RXR agonist with superior physicochemical properties

Max Lewandowski, Melania Carmina, Loris Knümann, Minh Sai, Sabine Willems, Till Kasch, Julius Pollinger, Stefan Knapp, Julian A. Marschner, Apirat Chaikuad, Daniel Merk

Version 1 posted 12 December 2023

211

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Biological and Medicinal Chemistry

Working Paper

Generating Customized Compound Libraries for Drug Discovery with Machine Intelligence

Michael Moret, Lukas Friedrich, Francesca Grisoni, Daniel Merk, Gisbert Schneider

Version 1 posted 07 November 2019

1,273

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Biological and Medicinal Chemistry

Working Paper

Light-controlled inhibition of the circadian regulator RORγ

Martin Reynders, Sabine Willems, Julian A. Marschner, Thomas Wein, Daniel Merk, Oliver Thorn-Seshold

Version 1 posted 31 July 2023

304

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Biological and Medicinal Chemistry

Working Paper

Structural optimization of oxaprozin for selective inverse Nurr1 agonism

Sabine Willems, Romy Busch, Felix Nawa, Marco Ballarotto, Felix F. Lillich, Till Kasch, Úrsula López-García, Julian A. Marschner, Lorena A. Rüger, Beatrice Renelt, Julia Ohrndorf, Silvia Arifi, Daniel Zaienne, Ewgenij Proschak, Jörg Pabel, Daniel Merk

Version 1 posted 30 July 2024

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Theoretical and Computational Chemistry

Working Paper

Beam Search Sampling for Molecular Design and Intrinsic Prioritization with Machine Intelligence

Michael Moret, Moritz Helmstädter, Francesca Grisoni, Gisbert Schneider, Daniel Merk

Version 1 posted 04 March 2021

754

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Biological and Medicinal Chemistry

Working Paper

Development of tailless homologue receptor (TLX) agonist chemical tools

Emily C. Hank, Minh Sai, Till Kasch, Isabelle Meijer, Julian Marschner, Daniel Merk

Version 1 posted 07 August 2024

154

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9 results in Daniel Merk in Authors: Daniel Merk

The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Caffeine and Istradefylline

Combining Generative Artificial Intelligence and On-Chip Synthesis for De Novo Drug Design

Deep interactome learning for de novo drug design

Structure-guided design of a highly potent RXR agonist with superior physicochemical properties

Generating Customized Compound Libraries for Drug Discovery with Machine Intelligence

Light-controlled inhibition of the circadian regulator RORγ

Structural optimization of oxaprozin for selective inverse Nurr1 agonism

Beam Search Sampling for Molecular Design and Intrinsic Prioritization with Machine Intelligence

Development of tailless homologue receptor (TLX) agonist chemical tools

9 results in Authors: Daniel Merk