Catalysis

Regioselective synthesis of 4-fluoro-1,5-substituted-1,2,3-triazoles from synthetic surrogates of 1-fluoroalkynes

Authors

Abstract

Here, we show that 1-fluoronitroalkenes can serve as synthetic surrogates of 1-fluoroalkynes in [3+2] cycloaddition reactions with organic azides facilitated by a catalytic amount of trifloroacetic acid. This work provides the first regioselective method to access 4-fluoro-1,5-substituted-1,2,3-triazoles.

Version notes

This is the third revised version.

Content

Thumbnail image of Fluoro-1,5-triazole_ChemRxiv_v3.pdf

Supplementary material

Thumbnail image of Supporting Information_ChemRxiv_v3 .pdf
Supporting Information ChemRxiv v3