Fluorinated 1,2,3-Triazoles from α-Fluoronitroalkenes as Surrogates of α-Fluoroalkynes via Regioselective Cycloaddition Reactions with Organic Azides

Sampad Jana; Sweta Adhikari; Michael Cox; Sudeshna Roy

doi:10.26434/chemrxiv.9738656.v2

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Fluorinated 1,2,3-Triazoles from α-Fluoronitroalkenes as Surrogates of α-Fluoroalkynes via Regioselective Cycloaddition Reactions with Organic Azides

30 September 2019, Version 2

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Abstract

Here we show that 1-fluoronitroalkenes can serve as synthetic surrogates of 1-fluoroalkynes in [3+2] cycloaddition reactions with organic azides facilitated by a catalytic amount of trifluoroacetic acid.

Keywords

fluorinated triazoles

fluoronitroalkenes

[3+2] cycloaddition

regioselective

fluorinated building blocks

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