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Regioselective synthesis of 4-fluoro-1,5-substituted-1,2,3-triazoles from synthetic surrogates of 1-fluoroalkynes

preprint
revised on 26.11.2019 and posted on 02.12.2019 by Sampad Jana, Sweta Adhikari, Michael Cox, Sudeshna Roy
Here, we show that 1-fluoronitroalkenes can serve as synthetic surrogates of 1-fluoroalkynes in [3+2] cycloaddition reactions with organic azides facilitated by a catalytic amount of trifloroacetic acid. This work provides the first regioselective method to access 4-fluoro-1,5-substituted-1,2,3-triazoles.

History

Email Address of Submitting Author

roy@olemiss.edu

Institution

University of Mississippi, School of Pharmacy

Country

United States

ORCID For Submitting Author

0000-0003-0237-4156

Declaration of Conflict of Interest

None

Version Notes

This is the third revised version.

Exports