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    1067 results for search term: covid

    Category: Biological and Medicinal Chemistry
    ,
    Working Paper
    , Title:

    COVID-KOP: Integrating Emerging COVID-19 Data with the ROBOKOP Database

    , Authors: Daniel Korn, Tesia Bobrowski, Michael Li, Yaphet Kebede, Patrick Wang, Phillips Owen, Gaurav Vaidya, Eugene Muratov, Rada Chirkova, Cristopher Bizon, Alexander Tropsha

    Extract found to contain search terms

    In response to the COVID -19 pandemic, we established COVID -KOP, a new knowledgebase integrating the existing ROBOKOP biomedical knowledge graph with information from recent biomedical literature on COVID -19 annotated in the CORD-19 collection. COVID -KOP can be used effectively to test new hypotheses concerning repurposing of known drugs and clinical drug candidates against COVID -19. COVID
    690
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    Category: Biological and Medicinal Chemistry
    ,
    Working Paper
    , Title:

    The NIH Lipo-COVID Study: A pilot NMR investigation of lipoprotein subfractions and other metabolites in patients with severe COVID-19.

    , Authors: Rami A. Ballout, Hyesik Kong, Maureen Sampson, James D. Otvos, Andrea Cox, Sean Agbor-Enoh, Alan T. Remaley

    Extract found to contain search terms

    Patients with severe COVID -19 have been reported to have low levels of total cholesterol, HDL-cholesterol, and LDL-cholesterol, but elevated levels of triglycerides. However, detailed characterization of particle number and size of the different plasma lipoproteins in patients with COVID -19 has yet to be reported. In this pilot investigational study, NMR spectroscopy was used to characterize lipoprotein particle numbers and sizes, as well as various metabolites, in 32 patients with severe COVID
    193
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    Category: Biological and Medicinal Chemistry
    ,
    Working Paper
    , Title:

    Gliptin Repurposing for COVID-19

    , Authors: Matthew Groves, Alexander Domling, Angel Jonathan Ruiz Moreno, Atilio Reyes Romero, Constantinos Neochoritis, Marco Velasco-Velázquez

    Extract found to contain search terms

    Drug repurposing aims to discover novel indications for already approved 34 drugs.3 The overwhelming advantage of drug repurposing is the much faster clinical approval, due to 35 already extensive knowledge of the physicochemical properties and behavior of the drug in humans. 36 Therefore, many groups have pursued a drug repurposing approach. This has led to several promising 37 drugs which are currently tested for COVID -19 in humans, including Favipiravir, Remdesivir, HIV protease 38 inhibitors, chloroquine or Tozilizumab.4,5 So far, however, none showed more than promising activity 39 based on low numbers of patients per trial. Additionally, a combination of Lopinavir and Ritonavir 40 (Kaletra®) – effective for HIV infection – failed in ~200 severe COVID
    971
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    3
    Citations
    Category: Biological and Medicinal Chemistry
    ,
    Review
    , Title:

    Fluorine in Medicinal Chemistry: In Perspective to COVID-19

    , Authors: CHENG ZHANG

    Extract found to contain search terms

    Over two years into the outbreak of COVID -19, the quest for effective and economical drugs has become starkly clear to reduce the risk of progression of coronavirus disease. A number of drugs have been investigated and they can be taken orally at home and be used after exposure to SARS-CoV-2 or at the first sign of COVID -19. Fluorinated oral anti-COVID -19 drugs—including Paxlovid, the first oral tablet for the treatment of COVID -19—is an important subgroup. Fluorine has been widely used in pharmaceuticals market and can lead to improved selectivity indices, increased lipophilicity, greater metabolic stability, and in this case the improved anti-COVID
    645
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    Category: Biological and Medicinal Chemistry
    ,
    Working Paper
    , Title:

    Repurposing of SARS Inhibitors Against COVID 19

    , Authors: Priyanka Rajbhar, Dikshant Singh, Ruchi Yadav

    Extract found to contain search terms

    Homology modelling and docking studies has been mainly done to identify the interaction and binding affinity of previous drugs and how they could act as a potential solution to stop the overall spread of the disease in case of pandemic like COVID
    655
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    1
    Citations
    Category: Biological and Medicinal Chemistry
    ,
    Working Paper
    , Title:

    Text and Network-Mining for COVID-19 Intervention Studies

    , Authors: Aditya Rao, VG Saipradeep, Thomas Joseph, Sujatha Kotte, Naveen Sivadasan, Rajgopal Srinivasan

    Extract found to contain search terms

    Amongst the novel repurposing drugs predicted, laninamivir and paritaprevir are possible COVID -19 anti-viral drugs while pranlukast was postulated to be a candidate for managing severe respiratory symptoms in COVID
    931
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