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Biological and Medicinal Chemistry

Working Paper

Proteolysis-Targeting Chimeras (PROTACs) Based on Macrocyclic Tetrapeptides Selectively Degrade Class I Histone Deacetylases 1–3

Martin Roatsch, Anja Vogelmann, Daniel Herp, Manfred Jung, Christian Adam Olsen

Version 1 posted 04 June 2020

1,681

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8

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Biological and Medicinal Chemistry

Working Paper

Epigenetic Target Profiler: A Web Server to Predict Epigenetic Targets of Small Molecules

Norberto Sánchez-Cruz, Jose L. Medina-Franco

Version 1 posted 07 January 2021

354

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Physical Chemistry

Working Paper

Photoinduced Intersystem Crossing in DNA Oxidative Lesions and Epigenetic Intermediates

Antonio Francés-Monerris, Mauricio Lineros-Rosa, Miguel Angél Miranda, Virginie Lhiaubet-Vallet, Antonio Monari

Version 1 posted 24 March 2020

321

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Biological and Medicinal Chemistry

Working Paper

Epigenetics Recording Varied Environment and Complex Cell Events is an Origin of Cellular Aging

xuejun guo, Dong Yang, Xiangyuan Zhang

Version 1 posted 03 December 2018

368

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Biological and Medicinal Chemistry

Working Paper

Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra Terminal Domain

Luke Adams, Lorna E. Wilkinson-White, Menachem J. Gunzburg, Stephen J. Headey, Martin J. Scanlon, Ben Capuano, Joel P. Mackay, Bradley Doak

Version 1 posted 25 March 2020

742

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Biological and Medicinal Chemistry

Working Paper

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Saleta Vazquez-Rodriguez, Miranda Wright, Catherine Rogers, Adam Cribbs, Srikannathasan Velupillai, Martin Philpott, Henry Lee, James E. Dunford, Kilian Huber, Matthew B. Robers, Jim Vasta, Marie-Laetitia Thezenas, Sarah Bonham, Benedikt M. Kessler, James Bennett, Oleg Fedorov, Florence Raynaud, Adam Donovan, Julian Blagg, Vassilios Bavetsias, Udo Oppermann, Akane Kawamura, Paul Brennan

Version 1 posted 11 September 2018

878

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Biological and Medicinal Chemistry

Working Paper

First fluorescent acetylspermidine deacetylation assay for HDAC10 identifies selective inhibitors with cellular target engagement

Daniel Herp, Johannes Ridinger, Dina Robaa, Stephen A. Shinsky, Karin Schmidtkunz, Talha Z. Yesiloglu, Theresa Bayer, Raphael R. Steimbach, Corey J. Herbst-Gervasoni, Annika Merz, Christophe Romier, Peter Sehr, Nikolas Gunkel, Aubry K. Miller, David W. Christianson, Ina Oehme, Wolfgang Sippl, Manfred Jung

Version 4 posted 30 March 2022

1,277

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Biological and Medicinal Chemistry

Working Paper

Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

Anna Skwarska, Ewen Calder, Deborah Sneddon, Hannah Bolland, Maria Odyniec, Ishna N. Mistry, Jennifer Martin, Lisa Folkes, Ester M. Hammond, Stuart Conway

Version 2 posted 23 March 2021

1,070

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Biological and Medicinal Chemistry

Working Paper

An Activity-based Probe Targeting Non-catalytic, Highly Conserved Amino Acid Residues Within Bromodomains

Melissa D’Ascenzio, Kathryn Pugh, Rebecca Konietzny, Georgina Berridge, Cynthia Tallant, Shaima Hashem, Octovia P. Monteiro, Jason R. Thomas, Markus Schirle, Stefan Knapp, Brian D. Marsden, Oleg Fedorov, Chas Bountra, Benedikt M. Kessler, Paul E. Brennan

Version 1 posted 17 October 2018

481

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Biological and Medicinal Chemistry

Working Paper

Potent and Selective N-Terminal BRD4 Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement

Huarui Cui, Anand Divakaran, Anil K. Pandey, Jorden A. Johnson, huda zahid, zachary hoell, mikael ellingson, ke shi, Hideki Aihara, Daniel A. Harki, william pomerantz

Version 1 posted 23 April 2020

538

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Refine Search

38 results in epigenetics in Keywords: epigenetics

Proteolysis-Targeting Chimeras (PROTACs) Based on Macrocyclic Tetrapeptides Selectively Degrade Class I Histone Deacetylases 1–3

Epigenetic Target Profiler: A Web Server to Predict Epigenetic Targets of Small Molecules

Photoinduced Intersystem Crossing in DNA Oxidative Lesions and Epigenetic Intermediates

Epigenetics Recording Varied Environment and Complex Cell Events is an Origin of Cellular Aging

Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra Terminal Domain

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

First fluorescent acetylspermidine deacetylation assay for HDAC10 identifies selective inhibitors with cellular target engagement

Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

An Activity-based Probe Targeting Non-catalytic, Highly Conserved Amino Acid Residues Within Bromodomains

Potent and Selective N-Terminal BRD4 Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement

38 results in Keywords: epigenetics