Search

Physical Chemistry

Working Paper

Photoinduced Intersystem Crossing in DNA Oxidative Lesions and Epigenetic Intermediates

Antonio Francés-Monerris, Mauricio Lineros-Rosa, Miguel Angél Miranda, Virginie Lhiaubet-Vallet, Antonio Monari

Version 1 posted 24 March 2020

321

Downloads

Biological and Medicinal Chemistry

Working Paper

Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra Terminal Domain

Luke Adams, Lorna E. Wilkinson-White, Menachem J. Gunzburg, Stephen J. Headey, Martin J. Scanlon, Ben Capuano, Joel P. Mackay, Bradley Doak

Version 1 posted 25 March 2020

743

Downloads

Biological and Medicinal Chemistry

Working Paper

Epigenetic Target Prediction with Accurate Machine Learning Models

Norberto Sánchez-Cruz, Jose L. Medina-Franco

Version 1 posted 06 January 2021

465

Downloads

Biological and Medicinal Chemistry

Working Paper

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2)

Daria Monaldi, Dante Rotili, Julien Lancelot, Martin Marek, Nathalie Wössner, Alessia Lucidi, Daniela Tomaselli, Elizabeth Ramos-Morales, Christophe Romier, Raymond J. Pierce, Antonello Mai, Manfred Jung

Version 2 posted 02 August 2019

988

Downloads

Biological and Medicinal Chemistry

Working Paper

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Saleta Vazquez-Rodriguez, Miranda Wright, Catherine Rogers, Adam Cribbs, Srikannathasan Velupillai, Martin Philpott, Henry Lee, James E. Dunford, Kilian Huber, Matthew B. Robers, Jim Vasta, Marie-Laetitia Thezenas, Sarah Bonham, Benedikt M. Kessler, James Bennett, Oleg Fedorov, Florence Raynaud, Adam Donovan, Julian Blagg, Vassilios Bavetsias, Udo Oppermann, Akane Kawamura, Paul Brennan

Version 1 posted 11 September 2018

878

Downloads

Biological and Medicinal Chemistry

Working Paper

Hypoxia-Activated Pro-Drugs of the KDAC Inhibitor Vorinostat (SAHA)

Ewen D. D. Calder, Anna Skwarska, Ishna N. Mistry, Deborah Sneddon, Stuart Conway, Ester M. Hammond

Version 1 posted 16 October 2019

631

Downloads

1

Citations

Biological and Medicinal Chemistry

Working Paper

Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells

Manfred Jung, Eva-Maria Herrlinger, Mirjam Hau, Desiree M. Redhaber, Gabriele Greve, Dominica Willmann, Simon Steimle, Michael Müller, Michael Lübbert, Cornelius Miething, Roland Schüle

Version 1 posted 24 October 2019

924

Downloads

Biological and Medicinal Chemistry

Working Paper

Proteolysis-Targeting Chimeras (PROTACs) Based on Macrocyclic Tetrapeptides Selectively Degrade Class I Histone Deacetylases 1–3

Martin Roatsch, Anja Vogelmann, Daniel Herp, Manfred Jung, Christian Adam Olsen

Version 1 posted 04 June 2020

1,683

Downloads

8

Citations

Biological and Medicinal Chemistry

Working Paper

Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases

Carlos Moreno-Yruela, Michael Bæk,, Adela-Eugenie Vrsanova, Hans M. Maric, Clemens Schulte, Christian Adam Olsen

Version 2 posted 19 November 2020

901

Downloads

Biological and Medicinal Chemistry

Working Paper

Controlling Intramolecular Interactions in the Design of Selective, High-Affinity, Ligands for the CREBBP Bromodomain

Michael Brand, James Clayton, Mustafa Moroglu, Matthias Schiedel, Sarah Picaud, Joseph Bluck, Anna Skwarska, Anthony Chan, Corentine Laurin, Amy Scorah, Larissa See, Timothy Rooney, Oleg Fedorov, Gabriella Perell, Prakriti Kalra, Wilian Cortopassi, Kirsten Christensen, Richard Cooper, Robert Paton, William Pomerantz, Philip Biggin, Ester M. Hammond, Panagis Filippakopoulos, Stuart Conway

Version 1 posted 06 April 2020

607

Downloads

3

Citations

Refine Search

39 results in epigenetics in Keywords: epigenetics

Photoinduced Intersystem Crossing in DNA Oxidative Lesions and Epigenetic Intermediates

Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra Terminal Domain

Epigenetic Target Prediction with Accurate Machine Learning Models

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2)

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Hypoxia-Activated Pro-Drugs of the KDAC Inhibitor Vorinostat (SAHA)

Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells

Proteolysis-Targeting Chimeras (PROTACs) Based on Macrocyclic Tetrapeptides Selectively Degrade Class I Histone Deacetylases 1–3

Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases

Controlling Intramolecular Interactions in the Design of Selective, High-Affinity, Ligands for the CREBBP Bromodomain

39 results in Keywords: epigenetics