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direct-to-biology

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4 results in Keywords: direct-to-biology

Organic Chemistry

An Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs

Rebecca Stevens, Enrique Bendito-Moll, David Battersby, Afjal Miah, Natalie Wellaway, Robert Law, Peter Stacey, Diana Klimaszewska, Justyna Macina, Glenn Burley, John Harling

Version 2 posted 01 September 2023

2,010

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1

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Organic Chemistry

Deconvoluting Low Yield from Weak Potency in Direct-to-Biology Workflows with Machine Learning

William McCorkindale, Mihajlo Filep, Nir London, Alpha A. Lee, Emma King-Smith

Version 2 posted 09 February 2024

400

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Organic Chemistry

Rapid Planning and Analysis of High-Throughput Experiment Arrays for Reaction Discovery

Babak Mahjour, Rui Zhang, Yuning Shen, Andrew McGrath, Ruheng Zhao, Osama G. Mohamed, Yingfu Lin, Zirong Zhang, James L. Douthwaite, Ashootosh Tripathi, Tim Cernak

Version 1 posted 02 December 2022

1,713

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1

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Biological and Medicinal Chemistry

Rapid PROTAC discovery platform: nanomole scale array synthesis and direct screening of reaction mixtures to facilitate the expedited discovery and follow-up of PROTAC hits.

Mateusz Plesniak, Emilia K. Taylor, Frederik Eisele, Christopher M. B. K. Kourra, Iacovos Michaelides, Alice Oram, Johan Wernevik, Zulma Santisteban-Valencia, Hannah Rowbottom, Nadia Mann, Linda Fredlund, Valentyna Pivnytska, Anna Noven, Mohammad Pirmoradian, Thomas Lundback, R. Ian Storer, Mariell Pettersson, Gian Marco De Donatis, Marie Rehnstrom

Version 1 posted 18 July 2023

2,038

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1

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