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Catalysis

Working Paper

Synthesis of gem-diboromethyl substituted bicyclo[1.1.1]pentanes and their application in palladium-catalysed cross couplings

Xiaoshen Ma, Yuan Jiang

Version 1 posted 01 November 2022

1,165

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Organic Chemistry

Working Paper

Fluoro-bicyclo[1.1.1]pentanes

Roman Bychek, Pavel Mykhailiuk

Version 1 posted 29 April 2022

2,001

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Organic Chemistry

Working Paper

General access to cubanes: ideal bioisosteres of ortho-, meta-, and para-substituted benzenes

Mario P. Wiesenfeldt, James. A. Rossi-Ashton, Ian B. Perry, Johannes Diesel, Olivia L. Garry, Florian Bartels, Susannah C. Coote, Xiaoshen Ma, Charles S. Yeung, David Jonathan Bennett, David W. C. MacMillan

Version 1 posted 23 January 2023

5,184

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1

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Organic Chemistry

Working Paper

Rapid and scalable halosulfonylation of strain-release reagents

Helena Pickford, Vasyl Ripenko, Ryan McNamee, Serhii Holovchuk, Amber Thompson, Russell Smith, Pavel Mykhailiuk, Edward Anderson

Version 1 posted 07 September 2022

1,445

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Organic Chemistry

Working Paper

Selective Synthesis of 1,3-Substituted Cuneanes: En Route to Potent Bioisosteres of m-Substituted Benzenes

Shota Nagasawa, Kan Fujiwara, Ryusei Maeyama, Ryosuke Segawa, Noriyasu Hirasawa, Takatsugu Hirokawa, Yoshiharu Iwabuchi

Version 2 posted 26 July 2023

1,074

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Biological and Medicinal Chemistry

Working Paper

Thiophosphate Bioisosteres of Inositol Hexakisphosphate Enhances Binding Affinity and Residence Time to Bacterial Virulence Factors.

Rebecca Cummer, Garvit Bhatt, Lauren M. Finn, Bettina G. Keller, Bhushan Nagar, Bastien Castagner

Version 3 posted 06 March 2025

241

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Organic Chemistry

Working Paper

C−F Bond Activation Enables Synthesis of Aryl Difluoromethyl Bicyclopentanes as Benzophenone-Type Bioisosteres

Mingshuo Chen, Yuang Cui, Xiaoping Chen, Rui Shang, Xiaheng Zhang

Version 1 posted 22 August 2023

1,556

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3

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Biological and Medicinal Chemistry

Working Paper

Active learning FEP using 3D-QSAR for prioritizing bioisosteres in medicinal chemistry

Venkata Krishnan Ramaswamy, Matthew Habgood, Mark Mackey

Version 2 posted 26 March 2025

532

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Organic Chemistry

Working Paper

Stellane at the Forefront: Derivatization and Reactivity Studies of a Promising Saturated Bioisostere of ortho‐Substituted Benzenes

Oleh Smyrnov, Kostiantyn Melnykov, Olexandr Pashenko, Dmytro Volochnyuk, Serhiy Ryabukhin

Version 1 posted 18 January 2024

386

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2

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Biological and Medicinal Chemistry

Working Paper

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication

Han Wee Ong, Xuan Yang, Jeffery Smith, Rebekah Dickmander, Jason Brown, Tammy Havener, Sharon Taft-Benz, Stefanie Howell, Marcia Sanders, Jacob Capener, Rafael Couñago, Edcon Chang, Andreas Krämer, Nathaniel Moorman, Mark Heise, Alison Axtman, David Drewry, Timothy Willson

Version 1 posted 24 April 2024

271

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23 results in bioisostere in Keywords: bioisostere

Synthesis of gem-diboromethyl substituted bicyclo[1.1.1]pentanes and their application in palladium-catalysed cross couplings

Fluoro-bicyclo[1.1.1]pentanes

General access to cubanes: ideal bioisosteres of ortho-, meta-, and para-substituted benzenes

Rapid and scalable halosulfonylation of strain-release reagents

Selective Synthesis of 1,3-Substituted Cuneanes: En Route to Potent Bioisosteres of m-Substituted Benzenes

Thiophosphate Bioisosteres of Inositol Hexakisphosphate Enhances Binding Affinity and Residence Time to Bacterial Virulence Factors.

C−F Bond Activation Enables Synthesis of Aryl Difluoromethyl Bicyclopentanes as Benzophenone-Type Bioisosteres

Active learning FEP using 3D-QSAR for prioritizing bioisosteres in medicinal chemistry

Stellane at the Forefront: Derivatization and Reactivity Studies of a Promising Saturated Bioisostere of ortho‐Substituted Benzenes

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication

23 results in Keywords: bioisostere