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Hit-Optimization Using Target-Directed Dynamic Combinatorial Chemistry: Development of Inhibitors of the Anti-Infective Target 1-Deoxy-D-Xylulose-5-Phosphate Synthase

Ravindra P. Jumde, Melissa Guardigni, Robin M. Gierse, Alaa Alhayek, Di Zhu, Zhoor Hamed, Sandra Johannsen, Walid A. M. Elgaher, Jörg Haupenthal, Anna K.H. Hirsch

Version 1 posted 22 July 2020

328

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Biological and Medicinal Chemistry

Working Paper

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

Lukas Junk, Volker Martin Schmiedel, Somraj Guha, Katharina Fischel, Peter Greb, Kristin Schwechel, Violetta Krisilia, Lasse van Geelen, Klaus Rumpel, Parvinder Kaur, Ramya V. Krishnamurthy, Shridhar Narayanan, Christiane Kofink, Andreas Mantoulidis, Philipp Biber, Gerhard Gmaschitz, Uli Kazmaier, Anton Meinhart, Julia Leodolter, David Hoi, Sabryna Junker, Francesca Ester Morreale, Tim Clausen, Rainer Kalscheuer, Harald Weinstabl, Guido Boehmelt

Version 2 posted 01 August 2023

1,695

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1

Citations

Biological and Medicinal Chemistry

Working Paper

De Novo Design of Type II Topoisomerase Inhibitors as Potential Antimicrobial Agents Targeting a Novel Binding Region

Kyle Orritt, Juliette Newell, Lipeng Feng, Thomas Germe, Lauren Abbott, Holly Jackson, Benjamin Bury, Anthony Maxwell, Martin McPhillie, Colin Fishwick

Version 2 posted 16 December 2021

452

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Biological and Medicinal Chemistry

Working Paper

Using Machine Learning to Predict the Antibacterial Activity of Ruthenium Complexes

Markus Orsi, Boon Shing Loh, Cheng Weng, Wee Han Ang, Angelo Frei

Version 2 posted 23 November 2023

479

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Biological and Medicinal Chemistry

Working Paper

Chasing new targets to fight antimicrobial resistance: identification of small molecules affecting the interaction of human hemoglobin with the IsdB hemophore of Staphylococcus aureus

Monica Cozzi, Maria Cristina Failla, Eleonora Gianquinto, Sandra Kovachka, Valeria Buoli Comani, Carlotta Compari, Omar De Bei, Roberta Giaccari, Francesco Marchesani, Marialaura Marchetti, Luca Ronda, Barbara Rolando, Massimo Baroni, Gabriele Cruciani, Barbara Campanini, Stefano Bettati, Serena Faggiano, Loretta Lazzarato, Francesca Spyrakis

Version 1 posted 31 January 2024

74

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Nanoscience

Review

Overview of nanotherapeutics for bacterial infections

José Muñoz-López, Cátia D. F. Lopes, Iris L. Batalha

Version 1 posted 06 February 2024

104

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Biological and Medicinal Chemistry

Working Paper

Catalytic Mechanism of the Colistin Resistance Protein MCR-1

Reynier Suardiaz, Emily Lythell, Philip Hinchliffed, Marc van der Kamp, James Spencer, Natalie Fey, Adrian Mulholland

Version 1 posted 22 December 2020

272

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Biological and Medicinal Chemistry

Working Paper

Inhibitors of the Elastase LasB for the treatment of Pseudomonas aeruginosa lung infections

Jelena Konstantinovic, Andreas M. Kany, Alaa Alhayek, Ahmed S. Abdelsamie, Asfandyar Sikandar, Katrin Voos, Yiwen Yao, Anastasia Andreas, Roya Shafiei, Brigitta Loretz, Esther Schönauer, Robert Bals, Hans Brandstetter, Rolf W. Hartmann, Christian Ducho, Claus-Michael Lehr, Christoph Beisswenger, Rolf Müller, Katharina Rox, Jörg Haupenthal, Anna Katharina Herta Hirsch

Version 1 posted 24 April 2023

279

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Biological and Medicinal Chemistry

Working Paper

Riboflavin-Vancomycin Conjugate Enables Simultaneous Antibiotic Photo-Release and Photodynamic Killing against Resistant Gram-Positive Pathogens

Bethany Mills, Alex Kiang, Syam Mohan P. C. Mohanan, Mark Bradley, Maxime Klausen

Version 2 posted 19 May 2023

218

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Theoretical and Computational Chemistry

Working Paper

Dynamic Behavior and Substrate Interactions of the Polymyxin Resistance Determinant MCR-1 Investigated by Extended Molecular Dynamics Simulations in the Membrane Environment

Emily Lythell, Reynier Suardíaz, Philip Hinchliffe, Sofia Oliveira, Marc van der Kamp, James Spencer, Adrian Mulholland

Version 1 posted 25 April 2024

18

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10 results in antimicrobial resistance in Keywords: antimicrobial resistance

Hit-Optimization Using Target-Directed Dynamic Combinatorial Chemistry: Development of Inhibitors of the Anti-Infective Target 1-Deoxy-D-Xylulose-5-Phosphate Synthase

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

De Novo Design of Type II Topoisomerase Inhibitors as Potential Antimicrobial Agents Targeting a Novel Binding Region

Using Machine Learning to Predict the Antibacterial Activity of Ruthenium Complexes

Chasing new targets to fight antimicrobial resistance: identification of small molecules affecting the interaction of human hemoglobin with the IsdB hemophore of Staphylococcus aureus

Overview of nanotherapeutics for bacterial infections

Catalytic Mechanism of the Colistin Resistance Protein MCR-1

Inhibitors of the Elastase LasB for the treatment of Pseudomonas aeruginosa lung infections

Riboflavin-Vancomycin Conjugate Enables Simultaneous Antibiotic Photo-Release and Photodynamic Killing against Resistant Gram-Positive Pathogens

Dynamic Behavior and Substrate Interactions of the Polymyxin Resistance Determinant MCR-1 Investigated by Extended Molecular Dynamics Simulations in the Membrane Environment

10 results in Keywords: antimicrobial resistance