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Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

Wei Shi, Guanghui Zong, Zhijian Hu, Sarah O’Keefe, Dale Tranter, Ludivine Baron, Michael Iannotti, Belinda Hall, Katherine Corfield, Anja Paatero, Mark Henderson, Peristera Roboti, Jianhong Zhou, Xianwei Sun, Mugunthan Govindarajan, Jason M. Rohde, Nicolas Blanchard, Rachel Simmonds, James Inglese, Yuchun Du, Caroline Demangel, Stephen High, Ville Paavilainen

Version 1 posted 14 January 2019

704

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Organic Chemistry

Working Paper

Electroaffinity Labeling: A New Platform for Chemoproteomic-based Target Identification

Yu Kawamata, Keun Ah Ryu, Gary Hermann, Alexander Sandahl, Julien Vantourout, Aleksandra Olow, La-Tonya Adams, Eva Rivera-Chao, Lee Roberts, Rob Oslund, Olugbeminiyi Fadeyi, phil baran

Version 1 posted 07 February 2022

5,558

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2

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Biological and Medicinal Chemistry

Working Paper

Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals the DNA Repair Protein XRCC5 as a Functional Target of Myrocin G

Daniel Abegg, Martin Tomanik, Nan Qiu, Dany Pechalrieu, Anton Shuster, Bruno Commare, Antonio Togni, Seth Herzon, Alexander Adibekian

Version 1 posted 14 September 2021

437

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Analytical Chemistry

Working Paper

Mapping peptide-protein interactions by amine-reactive cleavable photoaffinity reagents

Dimitris Korovesis, Hester Beard, Vanessa Gaspar, Suyuan Chen, Rene Zahedi, Steven Verhelst

Version 1 posted 04 May 2023

343

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Organic Chemistry

Working Paper

Total Synthesis and Chemoproteomics Connect Curcusone Diterpenes with Oncogenic Protein BRAT1

Chengsen Cui, Brendan G. Dwyer, Chang Liu, Daniel Abegg, Zhongjian Cai, Dominic Hoch, Xianglin Yin, Nan Qiu, Jieqing Liu, Alexander Adibekian, Mingji Dai

Version 1 posted 23 November 2020

997

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Biological and Medicinal Chemistry

Working Paper

Artificial Intelligence Recognizes β-Lapachone as an Allosteric 5- Lipoxygenase Inhibitor

Gonçalo Bernardes, Tiago Rodrigues, Markus Werner, Jakob Roth, Eduardo H. G. da Cruz, Marta C. Marques, Susana A. Lobo, Andreas Koeberle, Francisco Corzana, Eufrânio N. da Silva Júnior, Oliver Werz

Version 1 posted 27 March 2018

771

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Biological and Medicinal Chemistry

Working Paper

The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21

Esben Svenningsen, Rasmus Ottosen, Katrine Jørgensen, Marija Nisavic, Camilla Larsen, Bente Hansen, Yong Wang, Kresten Lindorff-Larsen, Thomas Tørring, Stephan Hacker, Johan Palmfeldt, Thomas Poulsen

Version 1 posted 01 July 2022

352

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Biological and Medicinal Chemistry

Working Paper

PROTAC technology as a Novel tool to identify the target of lathyrane diterpenoids

Yanli Wu, Yueying Yang, Wang Wang, Dejuan Sun, Mengzhu Zheng, Yirong Zhou, Jing Liang, Man Zhu, Hua Li, Lixia Chen

Version 1 posted 03 February 2022

1,202

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1

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Organic Chemistry

Working Paper

A Scalable Total Synthesis of Portimine A and B Reveals the Basis of Their Potent and Selective Anti-cancer Activity

Junchen Tang, Weichao Li, Tzu-Yuan Chiu, Zengwei Luo, Christine Chong, Qijia Wei, Francisco Martínez-Peña, Nathalia Gazaniga, Yi Yang See, Luke Lairson, Christopher Parker, Phil Baran

Version 1 posted 19 January 2023

6,620

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2

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Theoretical and Computational Chemistry

Working Paper

Accelerated Hit Identification with Target Evaluation, Deep Learning and Automated Labs: Prospective Validation in IRAK1

Gintautas Kamuntavičius, Alvaro Prat, Tanya Paquet, Orestis Bastas, Hisham Abdel Aty, Qing Sun, Carsten B. Andersen, John Harman, Marc Siladi, Dan Rines, Sarah J. L. Flatters, Roy Tal, Povilas Norvaisas

Version 5 posted 25 January 2024

1,180

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11 results in Target identification in Keywords: Target identification

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

Electroaffinity Labeling: A New Platform for Chemoproteomic-based Target Identification

Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals the DNA Repair Protein XRCC5 as a Functional Target of Myrocin G

Mapping peptide-protein interactions by amine-reactive cleavable photoaffinity reagents

Total Synthesis and Chemoproteomics Connect Curcusone Diterpenes with Oncogenic Protein BRAT1

Artificial Intelligence Recognizes β-Lapachone as an Allosteric 5- Lipoxygenase Inhibitor

The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21

PROTAC technology as a Novel tool to identify the target of lathyrane diterpenoids

A Scalable Total Synthesis of Portimine A and B Reveals the Basis of Their Potent and Selective Anti-cancer Activity

Accelerated Hit Identification with Target Evaluation, Deep Learning and Automated Labs: Prospective Validation in IRAK1

11 results in Keywords: Target identification