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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Satomi Imaide, Kristin M. Riching, Nikolai Makukhin, Vesna Vetma, Claire Whitworth, Scott J. Hughes, Nicole Trainor, Sarah D. Mahan, Nancy Murphy, Angus Cowan, Kwok-Ho Chan, Conner Craigon, Andrea Testa, Chiara Maniaci, Marjeta Urh, Danette L. Daniels, Alessio Ciulli

Version 2 posted 20 October 2021

4,582

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Biological and Medicinal Chemistry

Working Paper

Efficient targeted degradation via reversible and irreversible covalent PROTACs

Ronen Gabizon, Amit Shraga, Paul Gehrtz, Ella Livnah, Yamit Shorer, Neta Gurwicz, Liat Avram, Tamar Unger, Hila Aharoni, Shira Albeck, Alexander Brandis, Ziv Shulman, Ben- Zion Katz, Yair Herishanu, Nir London

Version 2 posted 17 March 2020

2,481

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Biological and Medicinal Chemistry

Working Paper

Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer

Hidetomo Yokoo, Norihito Shibata, Miyako Naganuma, Kiyonaga Fujii, Takahito Ito, Kosuke Aritake, Mikihiko Naito, Yosuke Demizu

Version 1 posted 05 October 2020

521

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Biological and Medicinal Chemistry

Working Paper

A comprehensive kinetic model for ternary complex catalysis

Eugene F. Douglass Jr., Chad J. Miller

Version 2 posted 27 January 2022

1,395

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2

Citations

Biological and Medicinal Chemistry

Working Paper

Cereblon versus VHL: Hijacking E3 Ligases Against Each Other Using PROTACs

Miriam Girardini, Chiara Maniaci, Scott J. Hughes, Andrea Testa, Alessio Ciulli

Version 2 posted 19 February 2019

1,726

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Biological and Medicinal Chemistry

Working Paper

PROTAC degraders of the METTL3-14 m6A-RNA methyltransferase

Francesco Errani, Annalisa Invernizzi, Marcin Herok, Elena Bochenkova, Fiona Stamm, Ivan Corbeski, Valeria Romanucci, Giovanni Di Fabio, František Zálešák, Amedeo Caflisch

Version 2 posted 06 February 2024

723

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Biological and Medicinal Chemistry

Working Paper

A Reliable and Sustainable Multicomponent Access to Protein Degraders

Irene Preet Bhela, Alice Ranza, Marta Serafini, Tracey PIRALI

Version 2 posted 25 October 2021

1,611

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Biological and Medicinal Chemistry

Working Paper

Leveraging dual-ligase recruitment to enhance degradation via a heterotrivalent PROTAC

Adam G. Bond, Miquel Muñoz i Ordoño, Celia M. Bisbach, Conner Craigon, Nikolai Makukhin, Elizabeth A. Caine, Manjula Nagala, Marjeta Urh, Georg E. Winter, Kristin M. Riching, Alessio Ciulli

Version 1 posted 21 August 2024

2,089

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Organic Chemistry

Working Paper

An Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs

Rebecca Stevens, Enrique Bendito-Moll, David Battersby, Afjal Miah, Natalie Wellaway, Robert Law, Peter Stacey, Diana Klimaszewska, Justyna Macina, Glenn Burley, John Harling

Version 2 posted 01 September 2023

2,226

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1

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Biological and Medicinal Chemistry

Working Paper

Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity

Victoria Klein, Adam Bond, Conner Craigon, R. Scott Lokey, Alessio Ciulli

Version 1 posted 05 July 2021

2,276

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2

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19 results in Protacs in Keywords: Protacs

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Efficient targeted degradation via reversible and irreversible covalent PROTACs

Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer

A comprehensive kinetic model for ternary complex catalysis

Cereblon versus VHL: Hijacking E3 Ligases Against Each Other Using PROTACs

PROTAC degraders of the METTL3-14 m6A-RNA methyltransferase

A Reliable and Sustainable Multicomponent Access to Protein Degraders

Leveraging dual-ligase recruitment to enhance degradation via a heterotrivalent PROTAC

An Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs

Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity

19 results in Keywords: Protacs