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Targeted Protein Degradation via a Covalent Reversible Degrader Based on Bardoxolone

Bingqi Tong, Mai Luo, Yi Xie, Jessica Spradlin, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Thomas J. Maimone, Daniel Nomura

Version 1 posted 02 April 2020

2,810

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3

Citations

Biological and Medicinal Chemistry

Working Paper

Targeted Degradation of Oncogenic KRASG12C by VHL-recruiting PROTACs

Michael J. Bond, Ling Chu, Dhanusha A. Nalawansha, Ke Li, Craig Crews

Version 1 posted 10 April 2020

3,685

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Biological and Medicinal Chemistry

Working Paper

HaloTag-Targeted Sirtuin Rearranging Ligand (SirReal) for the Development of Proteolysis Targeting Chimeras (PROTACs) Against the Lysine Deacetylase Sirtuin 2 (Sirt2)

Matthias Schiedel, Attila Lehotzky, Sándor Szunyogh, Judit Oláh, Sören Hammelmann, Nathalie Wössner, Dina Robaa, Oliver Einsle, Wolfgang Sippl, Judit Ovádi, Manfred Jung

Version 1 posted 27 May 2020

525

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Biological and Medicinal Chemistry

Working Paper

Predictive Modeling of PROTAC Cell Permeability with Machine Learning

Vasanthanathan Poongavanam, Florian Kölling, Anja Giese, Andreas H Göller, Lutz Lehmann, Daniel Meibom, Jan Kihlberg

Version 1 posted 11 October 2022

753

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1

Citations

Biological and Medicinal Chemistry

Working Paper

First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins

Paul O'Dowd, Graeme Sullivan, Daniel Rodrigues, Tríona Ní Chonghaile, Darren Griffith

Version 1 posted 26 June 2023

266

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Analytical Chemistry

Working Paper

Proximity Biosensor Assay for PROTAC Ternary Complex Analysis

Irene Ponzo, Alice Solda, Charlotte Crowe, Goran Dahl, Stefan Geschwindner, Alessio Ciulli, Ulrich Rant

Version 1 posted 06 March 2024

1,624

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Biological and Medicinal Chemistry

Working Paper

A method to identify small molecule/protein pairs susceptible to protein ubiquitination

Pinwen Cai, Basilius Sauter, Saule Zhanybekova, Dennis Gillingham

Version 1 posted 22 April 2024

455

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Biological and Medicinal Chemistry

Working Paper

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

Lukas Junk, Volker Martin Schmiedel, Somraj Guha, Katharina Fischel, Peter Greb, Kristin Schwechel, Violetta Krisilia, Lasse van Geelen, Klaus Rumpel, Parvinder Kaur, Ramya V. Krishnamurthy, Shridhar Narayanan, Christiane Kofink, Andreas Mantoulidis, Philipp Biber, Gerhard Gmaschitz, Uli Kazmaier, Anton Meinhart, Julia Leodolter, David Hoi, Sabryna Junker, Francesca Ester Morreale, Tim Clausen, Rainer Kalscheuer, Harald Weinstabl, Guido Boehmelt

Version 2 posted 01 August 2023

1,753

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1

Citations

Biological and Medicinal Chemistry

Working Paper

Biodegradable Polyphosphoester Micelles Act as Both Background-free 31P Magnetic Resonance Imaging Agents and Drug Nanocarriers

Olga Koshkina, Timo Rheinberger, Vera Flocke, Anton Windfelder, Pascal Bouvain, Naomi M. Hamelmann, Jos M.J. Paulusse, Hubert Hubert Gojzewski, Ulrich Flögel, Frederik Wurm

Version 1 posted 20 December 2022

292

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1

Citations

Biological and Medicinal Chemistry

Working Paper

Linker-dependent folding rationalizes PROTAC cell permeability

Vasanthanathan Poongavanam, Yoseph Atilaw, Stephan Siegel, Anja Giese, Lutz Lehmann, Daniel Meibom, Mate Erdelyi, Jan Kihlberg

Version 1 posted 04 May 2022

3,772

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Refine Search

43 results in Protac in Keywords: Protac

Targeted Protein Degradation via a Covalent Reversible Degrader Based on Bardoxolone

Targeted Degradation of Oncogenic KRASG12C by VHL-recruiting PROTACs

HaloTag-Targeted Sirtuin Rearranging Ligand (SirReal) for the Development of Proteolysis Targeting Chimeras (PROTACs) Against the Lysine Deacetylase Sirtuin 2 (Sirt2)

Predictive Modeling of PROTAC Cell Permeability with Machine Learning

First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins

Proximity Biosensor Assay for PROTAC Ternary Complex Analysis

A method to identify small molecule/protein pairs susceptible to protein ubiquitination

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

Biodegradable Polyphosphoester Micelles Act as Both Background-free 31P Magnetic Resonance Imaging Agents and Drug Nanocarriers

Linker-dependent folding rationalizes PROTAC cell permeability

43 results in Keywords: Protac