Search

Categories

Biological and Medicinal Chemistry

(2)

Theoretical and Computational Chemistry

(1)

Content Types

Working Paper

(2)

Keywords

Kinase Selectivity

Authors

2 results in Keywords: Kinase Selectivity

Biological and Medicinal Chemistry

Harnessing free energy calculations to achieve kinome-wide selectivity in drug discovery campaigns: Wee1 case study

Jennifer Knight, Anthony Clark, Jiashi Wang, Andrew Placzeck, Pieter Bos, Sathesh Bhat, Jeffrey Bell, Sarah Silvergleid, Wu Yin, Felicia Gray, Shaoxian Sun, Karen Akinsanya, Robert Abel, Aleksey Gerasyuto

Version 1 posted 20 August 2024

377

Downloads

Biological and Medicinal Chemistry

Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes

benjamin eduful, Sean O'Byrne, Louisa Temme, Christopher R. M. Asquith, Yi Liang, Alfredo Picado, Joseph Pilotte, Carrow Wells, William Zuercher, Carolina Catta-Preta, Priscila Zonzini Ramos, André Santiago, rafael Counago, Christopher G Langendorf, Kevin Nay, Jonathan S Oakhill, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Timothy M. Willson, Daniel E Frigo, John W. Scott, David Drewry

Version 1 posted 28 December 2020

480

Downloads