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Disrupters of the Thymidylate Synthase Homodimer Accelerate Its Proteasomal Degradation and Inhibit Cancer Growth.

Costantino Luca, Stefania Ferrari, Matteo Santucci, Outi M. Salo-Ahen, Carosati Emanuele, Silvia Franchini, Lauriola Angela, Cecilia Pozzi, Gaetano Marverti, Matteo Trande, Gozzi Gaia, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Remo Guerrini, Salvatore Pacifico, Rosaria Luciani, Filippo Genovese, Henrich Stefan, Alboni Silvia, Nuno Santarem, Anabela Cordeiro-da-Silva, Elisa Giovannetti, Godefridus Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert Stroud, Rebecca Wade, Stefano Mangani, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi

Version 1 posted 08 March 2021

445

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1

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Biological and Medicinal Chemistry

Working Paper

Thiourea and Guanidine Compounds and their Iridium Complexes in Drug-Resistant Cancer Cell Lines: Structure-Activity Relationships and Direct Luminescent Imaging

Samuel J. Thomas, Barbora Balonova, Jindrich Cinatl, Mark Wass, Christopher Serpell, Barry Blight, Martin Michaelis

Version 1 posted 11 July 2019

786

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Organic Chemistry

Working Paper

Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D

You-Chen Lin, Aubert Ribaucourt, Yasamin Moazami, Joshua Pierce

Version 2 posted 04 October 2019

848

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Biological and Medicinal Chemistry

Working Paper

Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia Cenocepacia

Kanhaya Lal, Rafael Bermo, Jonathan Cramer, Francesca Vasile, Beat Ernst, Anne Imberty, Anna Bernardi, Annabelle Varrot, Laura Belvisi

Version 1 posted 25 September 2020

300

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Biological and Medicinal Chemistry

Working Paper

Molecular Modeling of Structures and Interaction of Short Peptides and Sortase Family Protein of Enterococcus Faecalis: Basis for Developing Peptide-Based Therapeutics Against Multidrug Resistant Strains

Muthusaravanan S, Ram Kothandan, Kumaravel Kandaswamy, Cashlin Anna Suveetha Gnana Rajan, Janamitra Arjun, Rejoe Raymond

Version 1 posted 21 July 2020

339

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Biological and Medicinal Chemistry

Working Paper

Mechanism of Action of KL-50, a Novel Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers

Eric Huseman, Anna Lo, Olga Fedorova, James Elia, Susan Gueble, Kingson Lin, Ranjini Sundaram, Danielle Burgenske, Joonseok Oh, Jinchan Liu, Fabian Menges, Matthew Rees, Melissa Ronan, Jennifer Roth, Victor Batista, Jason Crawford, Jann Sarkaria, Anna Pyle, Ranjit Bindra, Seth Herzon

Version 1 posted 13 June 2023

613

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Biological and Medicinal Chemistry

Working Paper

A Cloud Computing Platform for Scalable Relative and Absolute Binding Free Energy Prediction: New Opportunities and Challenges for Drug Discovery

Zhixiong Lin, Junjie Zou, Chunwang Peng, Shuai Liu, Zhipeng Li, Xiao Wan, Dong Fang, Jian Yin, Gianpaolo Gobbo, Yongpan Chen, Jian Ma, Shuhao Wen, Peiyu Zhang, Mingjun Yang

Version 1 posted 16 October 2020

1,048

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1

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Biological and Medicinal Chemistry

Working Paper

A Prodrug Strategy for the In Vivo Imaging of Aldehyde Dehydrogenase Activity

Raul Pereira, Renee Flaherty, Richard Edwards, Hannah Greenwood, Adam Shuhendler, Timothy Witney

Version 2 posted 10 February 2022

370

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Analytical Chemistry

Review

CRISPR-based nucleic acid diagnostics for pathogens

Hao Yang, Yong Zhang, Xucong Teng, Hongwei Hou, Ruijie Deng, Jinghong Li

Version 1 posted 13 December 2022

667

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Biological and Medicinal Chemistry

Working Paper

Epitranscriptome-wide Approach for Identifying Specific Writer of RNA Modification as Knockdown Target for Resensitizing Glioblastoma Cells to Temozolomide Treatment

Norman Chiu, Jennifer Simpson, Frank Morales Shnaider, Renata Fleming, Bakhos Tannous

Version 1 posted 29 August 2024

83

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12 results in Drug Resistance in Keywords: Drug Resistance

Disrupters of the Thymidylate Synthase Homodimer Accelerate Its Proteasomal Degradation and Inhibit Cancer Growth.

Thiourea and Guanidine Compounds and their Iridium Complexes in Drug-Resistant Cancer Cell Lines: Structure-Activity Relationships and Direct Luminescent Imaging

Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D

Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia Cenocepacia

Molecular Modeling of Structures and Interaction of Short Peptides and Sortase Family Protein of Enterococcus Faecalis: Basis for Developing Peptide-Based Therapeutics Against Multidrug Resistant Strains

Mechanism of Action of KL-50, a Novel Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers

A Cloud Computing Platform for Scalable Relative and Absolute Binding Free Energy Prediction: New Opportunities and Challenges for Drug Discovery

A Prodrug Strategy for the In Vivo Imaging of Aldehyde Dehydrogenase Activity

CRISPR-based nucleic acid diagnostics for pathogens

Epitranscriptome-wide Approach for Identifying Specific Writer of RNA Modification as Knockdown Target for Resensitizing Glioblastoma Cells to Temozolomide Treatment

12 results in Keywords: Drug Resistance