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Organic Chemistry

Working Paper

Synthesis of 6-azaindoles via electrophilic [4+1]-cyclization of 3-amino-4-methyl pyridines: scope and limitations

Sergey Ivonin, Volodymyr Voloshchuk, Eduard Rusanov, Sergey Suikov, Serhiy Ryabukhin, Dmytro Volochnyuk

Version 1 posted 31 July 2023

263

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Organic Chemistry

Working Paper

3,3-Difluorooxetane – a Versatile Functional Group for Bioisosteric Replacements in Drug Discovery

Oleksandr Liashuk, Anastasiya Fedinchyk, Kostiantyn Melnykov, Maksym Herasymchuk, Diana Alieksieieva, Dmytro Lesyk, Yulia Bas, Tatiana Keda, Andriy Yatsymyrskiy, Yuliia Holota, Petro Borysko, Volodymyr Yarmolchuk, Oleksandr Grygorenko

Version 1 posted 14 August 2024

1,241

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Organic Chemistry

Working Paper

gem-Difluorinated Saturated O-Heterocycles – Promising Fragments for Bioisosteric Replacements in Drug Discovery

Kostiantyn Melnykov, Oleksandr Liashuk, Serhii Holovach, Valeriia Shatnia, Artur Horbenko, Dmytro Lesyk, Varvara Melnyk, Daniil Skrypnik, Anna Beshtynarska, Petro Borysko, Oleksandr Viniichuk, Oleksandr Grygorenko

Version 1 posted 28 November 2024

377

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Organic Chemistry

Working Paper

Multigram Synthesis of 4,4-disubstituted-3-oxopyrrolidones – efficient starting material for diverse 3 functionalized pyrrolidones

Semen Bondarenko, Anatolii Fedorchenko, Pavlo Novosolov, Oleksandr Marchenko, Anton Hanopolskyi, Yulian Volovenko, Dmytro Volochnyuk, Serhiy Ryabukhin

Version 1 posted 17 January 2024

228

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1

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Organic Chemistry

Working Paper

Oxetane as a part of modern medicinal chemistry toolbox: the case of 3,3-disubstituted building blocks

Eduard Litskan, Oleksandr Semenchenko, Serhii Lynnyk, Dmitry Granat, Bohdan Vashchenko, Anastasiia Hoida, Daria Tolmachova, Dmytro Leha, Oleksandr Grygorenko, Dmytro Volochnyuk, Serhiy Ryabukhin

Version 1 posted 12 November 2024

1,243

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Organic Chemistry

Working Paper

Copper-mediated C–C Coupling of Alkenyl Boronates and Bromodifluoroacetates

Yevhen Yurov, Kamila Laniush, Oleksandr Hryschuk, Oleksandr Liashuk, Oleksandr Grygorenko

Version 1 posted 29 November 2024

235

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Organic Chemistry

Working Paper

Synthesis of 1,2,5,6- and 1,4,5,8-Anthracenetetrone: Building Blocks for π-Conjugated Small Molecules and Polymers

Florian Glöcklhofer, Berthold Stöger, Johannes Fröhlich

Version 1 posted 03 May 2018

747

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Materials Chemistry

Working Paper

Data-driven discovery of organic electronic materials enabled by hybrid top-down/bottom-up design

J. Terence Blaskovits, Ruben Laplaza, Sergi Vela, Clémence Corminboeuf

Version 1 posted 05 December 2022

680

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3

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Theoretical and Computational Chemistry

Working Paper

A close-up look at the chemical space of commercially available building blocks for medicinal chemistry

Yuliana Zabolotna, Dmitriy Volochnyuk, Sergey Ryabukhin, Dragos Horvath, Kostiantyn Gavrylenko, Gilles Marcou, Yurii Moroz, Olexandr Oksiuta, Alexandre Varnek

Version 1 posted 09 July 2021

1,511

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Organic Chemistry

Working Paper

Stellane at the Forefront: Derivatization and Reactivity Studies of a Promising Saturated Bioisostere of ortho‐Substituted Benzenes

Oleh Smyrnov, Kostiantyn Melnykov, Olexandr Pashenko, Dmytro Volochnyuk, Serhiy Ryabukhin

Version 1 posted 18 January 2024

334

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1

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Refine Search

11 results in Building blocks in Keywords: Building blocks

Synthesis of 6-azaindoles via electrophilic [4+1]-cyclization of 3-amino-4-methyl pyridines: scope and limitations

3,3-Difluorooxetane – a Versatile Functional Group for Bioisosteric Replacements in Drug Discovery

gem-Difluorinated Saturated O-Heterocycles – Promising Fragments for Bioisosteric Replacements in Drug Discovery

Multigram Synthesis of 4,4-disubstituted-3-oxopyrrolidones – efficient starting material for diverse 3 functionalized pyrrolidones

Oxetane as a part of modern medicinal chemistry toolbox: the case of 3,3-disubstituted building blocks

Copper-mediated C–C Coupling of Alkenyl Boronates and Bromodifluoroacetates

Synthesis of 1,2,5,6- and 1,4,5,8-Anthracenetetrone: Building Blocks for π-Conjugated Small Molecules and Polymers

Data-driven discovery of organic electronic materials enabled by hybrid top-down/bottom-up design

A close-up look at the chemical space of commercially available building blocks for medicinal chemistry

Stellane at the Forefront: Derivatization and Reactivity Studies of a Promising Saturated Bioisostere of ortho‐Substituted Benzenes

11 results in Keywords: Building blocks