Search

Organic Chemistry

Working Paper

Synthesis of Multi-Substituted Bicycloalkyl Boronates: An Intramolecular Coupling Approach to Alkyl Bioisosteres

Yangyang Yang, Jet Tsien, Jonathan Hughes, Byron Peters, Rohan Merchant, Tian Qin

Version 1 posted 08 February 2021

2,697

Downloads

4

Citations

Organic Chemistry

Working Paper

Boronic Acid with High Oxidative Stability and Utility in Biological Contexts

Brian Graham, Ian W. Windsor, Brian Gold, Ronald Raines

Version 1 posted 07 December 2020

698

Downloads

Organic Chemistry

Working Paper

3,3-Difluorooxetane – a Versatile Functional Group for Bioisosteric Replacements in Drug Discovery

Oleksandr Liashuk, Anastasiya Fedinchyk, Kostiantyn Melnykov, Maksym Herasymchuk, Diana Alieksieieva, Dmytro Lesyk, Yulia Bas, Tatiana Keda, Andriy Yatsymyrskiy, Yuliia Holota, Petro Borysko, Volodymyr Yarmolchuk, Oleksandr Grygorenko

Version 1 posted 14 August 2024

1,182

Downloads

Organic Chemistry

Working Paper

Organometallic Bridge Diversification of Bicyclo[1.1.1]pentanes

Joseph Anderson, Darren Poole, Gemma Cook, John Murphy, Nicholas Measom

Version 1 posted 21 August 2023

1,214

Downloads

1

Citations

Organic Chemistry

Working Paper

Enantioselective photocatalytic synthesis of bicyclo[2.1.1]hexanes as orthodisubstituted benzene bioisosteres with improved biological activity

Pablo Garrido-Garcia, Irene Quiros, Paula Milan-Rois, Alvaro Somoza, Israel Fernandez, Thomas Rigotti, Mariola Tortosa

Version 1 posted 03 October 2023

1,440

Downloads

1

Citations

Organic Chemistry

Working Paper

Visible Light Promoted Functionalisation of Carbon-Carbon Sigma Bonds

Jeremy Nugent, Carlos Arroniz, Bethany Shire, Alistair J. Sterling, Helena D. Pickford, Marie L. J. Wong, Steven J. Mansfield, Dimitri F. J. Caputo, Benjamin Owen, James J. Mousseau, Fernanda Duarte, Edward Anderson

Version 1 posted 08 April 2019

1,900

Downloads

Catalysis

Working Paper

Polysubstituted Benzene Bioisosteres and Beyond: Photochemical Access to Bicyclo[2.1.1]hexanes

Marius Reinhold, Justin Steinebach, Johannes Walker

Version 1 posted 13 March 2023

981

Downloads

3

Citations

Biological and Medicinal Chemistry

Working Paper

Investigation of Carboxylic Acid Isosteres for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

Nima Rajabi, Alexander L. Nielsen, Tobias N. Hansen, Huy T. Nguyen, Michael Bæk, Julie E. Bolding, Oskar Ø. Bahlke, Sylvester E. G. Petersen, Christian R. O. Bartling, Kristian Strømgaard, Christian Adam Olsen

Version 1 posted 24 November 2021

394

Downloads

Biological and Medicinal Chemistry

Working Paper

Bridge Heteroarylation of Bicyclo[1.1.1]pentane Derivatives

Joseph Anderson, Nicholas Measom, John Murphy, Darren Poole

Version 1 posted 21 December 2022

1,164

Downloads

Biological and Medicinal Chemistry

Working Paper

Bioisostere Effects on the EPSA of Common Permeability-Limiting Groups

Andrew Ecker, Dorothy Levorse, Daniel Victor, Matthew Mitcheltree

Version 1 posted 16 March 2022

3,204

Downloads

1

Citations

Refine Search

20 results in Bioisosteres in Keywords: Bioisosteres

Synthesis of Multi-Substituted Bicycloalkyl Boronates: An Intramolecular Coupling Approach to Alkyl Bioisosteres

Boronic Acid with High Oxidative Stability and Utility in Biological Contexts

3,3-Difluorooxetane – a Versatile Functional Group for Bioisosteric Replacements in Drug Discovery

Organometallic Bridge Diversification of Bicyclo[1.1.1]pentanes

Enantioselective photocatalytic synthesis of bicyclo[2.1.1]hexanes as orthodisubstituted benzene bioisosteres with improved biological activity

Visible Light Promoted Functionalisation of Carbon-Carbon Sigma Bonds

Polysubstituted Benzene Bioisosteres and Beyond: Photochemical Access to Bicyclo[2.1.1]hexanes

Investigation of Carboxylic Acid Isosteres for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

Bridge Heteroarylation of Bicyclo[1.1.1]pentane Derivatives

Bioisostere Effects on the EPSA of Common Permeability-Limiting Groups

20 results in Keywords: Bioisosteres