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9 results in Authors: Shigehiro Kawashima

Biological and Medicinal Chemistry

Working Paper

Unimolecular Chemiexcited Oxygenation of Pathogenic Amyloids

Hiroki Umeda, Kayo Suda, Daisuke Yokogawa, Shigehiro A. Kawashima, Harunobu Mitsunuma, Yuki Yamanashi, Motomu Kanai

Version 1 posted 13 March 2024

370

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Biological and Medicinal Chemistry

Working Paper

Chemical catalyst manipulating cancer epigenome and transcription

Yuki Yamanashi, Shinpei Takamaru, Atsushi Okabe, Satoshi Kaito, Yuto Azumaya, Yugo Kamimura, Kenzo Yamatsugu, Tomoya Kujirai, Hitoshi Kurumizaka, Atsushi Iwama, Atsushi Kaneda, Shigehiro Kawashima, Motomu Kanai

Version 2 posted 31 May 2024

363

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Biological and Medicinal Chemistry

Working Paper

Small molecule amyloid disrupters demonstrate therapeutic efficacy for transthyretin amyloidosis

Mina Yamane, Hiroki Umeda, Moe Toyobe, Atsushi Iwai, Genki Kudo, Harunobu Mitsunuma, Yukiko Hori, Taisuke Tomita, Mineyuki Mizuguchi, Masamitsu Okada, Mitsuharu Ueda, Yukio Ando, Shigehiro A. Kawashima, Youhei Sohma, Takatsugu Hirokawa, Kunitoshi Yamanaka, Motomu Kanai

Version 1 posted 08 April 2024

232

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Biological and Medicinal Chemistry

Working Paper

Logics for Developing Regioselective Histone Acetylating Catalysts

Tamiko Nozaki, Mayu Onoda, Misuzu Habazaki, Yuma Takeuchi, Hisashi Ishida, Yuko Sato, Tomoya Kujirai, Kayo Hanada, Kenzo Yamatsugu, Hitoshi Kurumizaka, Hiroshi Kimura, Hidetoshi Kono, Shigehiro Kawashima, Motomu Kanai

Version 1 posted 27 May 2024

146

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Organic Chemistry

Working Paper

A chemical catalyst enabling histone acylation with endogenous Acyl-CoA

Misuzu Habazaki, Shinsuke Mizumoto, Hidetoshi Kajino, Tomoya Kujirai, Hitoshi Kurumizaka, Shigehiro Kawashima, Kenzo Yamatsugu, Motomu Kanai

Version 1 posted 12 May 2022

433

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Biological and Medicinal Chemistry

Working Paper

Chemical catalyst/protein hybrid as artificial histone-modifying enzyme for epigenome manipulation

Akiko Fujimura, Hisashi Ishida, Tamiko Nozaki, Yuto Azumaya, Tadashi Ishiguro, Tomoya Kujirai, Hitoshi Kurumizaka, Hidetoshi Kono, Kenzo Yamatsugu, Shigehiro Kawashima, Motomu Kanai

Version 1 posted 11 May 2022

317

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Citations

Agriculture and Food Chemistry

Working Paper

Quantitative Assays for Catalytic Photo-Oxygenation of Alzheimer Disease-Related Tau Proteins

Hiroki Umeda, Taka Sawazaki, Masahiro Furuta, Takanobu Suzuki, Shigehiro Kawashima, Harunobu Mitsunuma, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Motomu Kanai

Version 1 posted 12 May 2023

139

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Organic Chemistry

Working Paper

A Single-Step Asymmetric Phosphodiester Synthesis from Alcohols with Phosphoenolpyruvate Phosphodiester

Kohei Fujiyoshi, Shigehiro Kawashima, Kenzo Yamatsugu, Motomu Kanai

Version 1 posted 05 May 2021

413

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Citations

Biological and Medicinal Chemistry

Working Paper

Live-Cell Epigenome Manipulation by Synthetic Histone Acylation Catalyst System

Yusuke Fujiwara, Yuki Yamanashi, Yuko Sato, Tomoya Kujirai, Hitoshi Kurumizaka, Hiroshi Kimura, Kenzo Yamatsugu, Shigehiro Kawashima, Motomu Kanai

Version 1 posted 27 April 2020

586

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9 results in Shigehiro Kawashima in Authors: Shigehiro Kawashima

Unimolecular Chemiexcited Oxygenation of Pathogenic Amyloids

Chemical catalyst manipulating cancer epigenome and transcription

Small molecule amyloid disrupters demonstrate therapeutic efficacy for transthyretin amyloidosis

Logics for Developing Regioselective Histone Acetylating Catalysts

A chemical catalyst enabling histone acylation with endogenous Acyl-CoA

Chemical catalyst/protein hybrid as artificial histone-modifying enzyme for epigenome manipulation

Quantitative Assays for Catalytic Photo-Oxygenation of Alzheimer Disease-Related Tau Proteins

A Single-Step Asymmetric Phosphodiester Synthesis from Alcohols with Phosphoenolpyruvate Phosphodiester

Live-Cell Epigenome Manipulation by Synthetic Histone Acylation Catalyst System

9 results in Authors: Shigehiro Kawashima