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A Single-Step Asymmetric Phosphodiester Synthesis from Alcohols with Phosphoenolpyruvate Phosphodiester

05 May 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Phosphodiester are important structural motifs observed in a diverse field of molecular science. It is, thus, important to develop a simple and robust way to synthesize them from corresponding alcohols. Here we report a single-step asymmetric phosphodiester synthesis from alcohols with phosphoenolpyruvate phosphodiesters as phosphoryl donors. This transformation allows for the use of various functionalized alcohols as substrates, and would be useful for diverse fields including biology and medicine.

Keywords

Phosphorylation
alcohol
phosphodiester
phosphoenolpyruvate
pentacoordinate phosphorous

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Version History

May 05, 2021 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.14531847.v1
D O I: 10.26434/chemrxiv.14531847.v1 [opens in a new tab]

Funding

JP17K15420
JP20H00489
SUNBOR GRANT

Author’s competing interest statement

The authors declare no competing financial interests.

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