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Live-Cell Epigenome Manipulation by Synthetic Histone Acylation Catalyst System

Yusuke Fujiwara, Yuki Yamanashi, Yuko Sato, Tomoya Kujirai, Hitoshi Kurumizaka, Hiroshi Kimura, Kenzo Yamatsugu, Shigehiro Kawashima, Motomu Kanai

Version 1 posted 27 April 2020

565

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Organic Chemistry

Working Paper

A Single-Step Asymmetric Phosphodiester Synthesis from Alcohols with Phosphoenolpyruvate Phosphodiester

Kohei Fujiyoshi, Shigehiro Kawashima, Kenzo Yamatsugu, Motomu Kanai

Version 1 posted 05 May 2021

358

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1

Citations

Biological and Medicinal Chemistry

Working Paper

Chemical catalyst/protein hybrid as artificial histone-modifying enzyme for epigenome manipulation

Akiko Fujimura, Hisashi Ishida, Tamiko Nozaki, Yuto Azumaya, Tadashi Ishiguro, Tomoya Kujirai, Hitoshi Kurumizaka, Hidetoshi Kono, Kenzo Yamatsugu, Shigehiro Kawashima, Motomu Kanai

Version 1 posted 11 May 2022

288

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1

Citations

Organic Chemistry

Working Paper

A chemical catalyst enabling histone acylation with endogenous Acyl-CoA

Misuzu Habazaki, Shinsuke Mizumoto, Hidetoshi Kajino, Tomoya Kujirai, Hitoshi Kurumizaka, Shigehiro Kawashima, Kenzo Yamatsugu, Motomu Kanai

Version 1 posted 12 May 2022

406

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Agriculture and Food Chemistry

Working Paper

Quantitative Assays for Catalytic Photo-Oxygenation of Alzheimer Disease-Related Tau Proteins

Hiroki Umeda, Taka Sawazaki, Masahiro Furuta, Takanobu Suzuki, Shigehiro Kawashima, Harunobu Mitsunuma, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Motomu Kanai

Version 1 posted 12 May 2023

98

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Biological and Medicinal Chemistry

Working Paper

Unimolecular Chemiexcited Oxygenation of Pathogenic Amyloids

Hiroki Umeda, Kayo Suda, Daisuke Yokogawa, Shigehiro A. Kawashima, Harunobu Mitsunuma, Yuki Yamanashi, Motomu Kanai

Version 1 posted 13 March 2024

91

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Biological and Medicinal Chemistry

Working Paper

Small molecule amyloid disrupters demonstrate therapeutic efficacy for transthyretin amyloidosis

Mina Yamane, Hiroki Umeda, Moe Toyobe, Atsushi Iwai, Genki Kudo, Harunobu Mitsunuma, Yukiko Hori, Taisuke Tomita, Mineyuki Mizuguchi, Masamitsu Okada, Mitsuharu Ueda, Yukio Ando, Shigehiro A. Kawashima, Youhei Sohma, Takatsugu Hirokawa, Kunitoshi Yamanaka, Motomu Kanai

Version 1 posted 08 April 2024

105

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7 results in Shigehiro Kawashima in Authors: Shigehiro Kawashima

Live-Cell Epigenome Manipulation by Synthetic Histone Acylation Catalyst System

A Single-Step Asymmetric Phosphodiester Synthesis from Alcohols with Phosphoenolpyruvate Phosphodiester

Chemical catalyst/protein hybrid as artificial histone-modifying enzyme for epigenome manipulation

A chemical catalyst enabling histone acylation with endogenous Acyl-CoA

Quantitative Assays for Catalytic Photo-Oxygenation of Alzheimer Disease-Related Tau Proteins

Unimolecular Chemiexcited Oxygenation of Pathogenic Amyloids

Small molecule amyloid disrupters demonstrate therapeutic efficacy for transthyretin amyloidosis

7 results in Authors: Shigehiro Kawashima