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Biological and Medicinal Chemistry

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Preparation and Application of an Inexpensive α-Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis

Nicholas Yates, Matthew Warnes, Reuben Breetveld, Christopher Spicer, Nathalie Signoret, Martin Fascione

Version 1 posted 30 November 2022

205

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Biological and Medicinal Chemistry

Working Paper

Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-Fluorinated Monosaccharides

Tessa Keenan, Fabio Parmeggiani, Julien Malassis, Clement Fontenelle, Jean-Baptiste Vendeville, Wendy Offen, Peter Both, kun huang, Andrea Marchesi, Alex Heyam, Carl Young, Simon J. Charnock, Gideon J. Davies, Bruno Linclau, Sabine Flitsch, Martin Fascione

Version 1 posted 09 March 2020

536

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Biological and Medicinal Chemistry

Working Paper

Chemoenzymatic synthesis of an unnatural Manb1,4GlcNAc library using a glycoside phosphorylase with "reverse thiophosphorylase" activity

Tessa Keenan, Natasha Hatton, Jack Porter, Jean-Baptiste Vendeville, David Wheatley, Mattia Ghirardello, Alice Wahart, Sanaz Ahmadipour, Julia Walton, Carmen Galan, Bruno Linclau, Gavin Miller, Martin Fascione

Version 1 posted 07 February 2023

292

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Biological and Medicinal Chemistry

Working Paper

Selectivity and stability of N-terminal targeting protein modification chemistries

Lydia Barber, Nicholas Yates, Martin Fascione, Alison Parkin, Glyn Hemsworth, Paul Genever, Christopher Spicer

Version 1 posted 23 August 2022

362

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Biological and Medicinal Chemistry

Working Paper

Site-Selective C-C Modification of Proteins at Neutral pH Using Organocatalyst-Mediated Cross Aldol Ligations

Martin A. Fascione, Richard J. Spears, Robin L. Brabham, Darshita Budhadev, Tessa Keenan, Sophie McKenna, Julia Walton, James. A. Brannigan, A. Marek Brzozowski, Anthony J. Wilkinson, Michael Plevin

Version 1 posted 09 February 2018

723

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Organic Chemistry

Working Paper

A ‘glyco-fluorine’ code revealing differential recognition by glycan binding partners

Kristian Hollingsworth, Antonio Di Maio, Sarah-Jane Richards, Jean-Baptiste Vendeville, David E. Wheatley, Claire E. Council, Tessa Keenan, Helene Ledru, Harriet Chidwick, Huang Kun, Fabio Parmeggiani, Andrea Marchesi, Wengang Chai, Ryan McBerney, Tomasz P. Kaminski, Matthew R. Balmforth, Alexandra Tamasanu, Simon Charnock, Stuart L. Warriner, Michael E. Webb, Martin A. Fascione, Sabine Flitsch, M. Carmen Galan, Ten Feizi, Matthew I. Gibson, Yan Liu, W. Bruce Turnbull, Bruno Linclau

Version 1 posted 10 July 2023

478

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Biological and Medicinal Chemistry

Working Paper

The retaining Pse5Ac7Ac pseudaminyltransferase KpsS1 defines a new glycosyltransferase family (GTXXX)

Abigail Walklett, Emily Flack, Harriet Chidwick, Natasha Hatton, Tessa Keenan, Darshita Budhadev, Julia Walton, Gavin Thomas, Martin Fascione

Version 1 posted 04 December 2023

133

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Biological and Medicinal Chemistry

Working Paper

Mannose Presenting ‘Glyco-Colicins’ Convert the Bacterial Cell Surface into a Multivalent Adsorption Site for Adherent Bacteria

Natasha Hatton, Joe Nabarro, Nicholas Yates, Alison Parkin, Laurence Wilson, Christoph Baumann, Martin Fascione

Version 1 posted 17 April 2024

73

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Biological and Medicinal Chemistry

Working Paper

A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein A-Oxo Aldehydes in Competing A-Oxo-Mannich and Catalyst-Free Aldol Ligations

Tessa Keenan, Richard Spears, Saeed Akkad, Clare Mahon, Natasha E. Hatton, Julia Walton, Amanda Noble, Nick Yates, Christoph G. Baumann, Alison Parkin, Nathalie Signoret, Martin Fascione

Version 1 posted 07 June 2021

276

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Organic Chemistry

Working Paper

Catalyst-free site-selective cross-aldol bioconjugations

Nicholas D. Yates, Saeed Akkad, Amanda Noble, Tessa Keenan, Natasha E. Hatton, Nathalie Signoret, Martin Fascione

Version 1 posted 16 June 2022

261

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10 results in Martin A. Fascione in Authors: Martin A. Fascione

Preparation and Application of an Inexpensive α-Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis

Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-Fluorinated Monosaccharides

Chemoenzymatic synthesis of an unnatural Manb1,4GlcNAc library using a glycoside phosphorylase with "reverse thiophosphorylase" activity

Selectivity and stability of N-terminal targeting protein modification chemistries

Site-Selective C-C Modification of Proteins at Neutral pH Using Organocatalyst-Mediated Cross Aldol Ligations

A ‘glyco-fluorine’ code revealing differential recognition by glycan binding partners

The retaining Pse5Ac7Ac pseudaminyltransferase KpsS1 defines a new glycosyltransferase family (GTXXX)

Mannose Presenting ‘Glyco-Colicins’ Convert the Bacterial Cell Surface into a Multivalent Adsorption Site for Adherent Bacteria

A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein A-Oxo Aldehydes in Competing A-Oxo-Mannich and Catalyst-Free Aldol Ligations

Catalyst-free site-selective cross-aldol bioconjugations

10 results in Authors: Martin A. Fascione