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Biological and Medicinal Chemistry

Working Paper

Small Changes in Hydration Determine Cephalosporinase Activity of OXA-48 β-Lactamases

Viivi H. A. Hirvonen, Adrian Mulholland, James Spencer, Marc W. van der Kamp

460

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Biological and Medicinal Chemistry

Working Paper

Catalytic Mechanism of the Colistin Resistance Protein MCR-1

Reynier Suardiaz, Emily Lythell, Philip Hinchliffed, Marc van der Kamp, James Spencer, Natalie Fey, Adrian Mulholland

253

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Biological and Medicinal Chemistry

Working Paper

Multiscale simulations identify origins of differential carbapenem hydrolysis by the OXA-48 β-lactamase

Viivi Hirvonen, Tal Moshe Weizmann, Adrian Mulholland, James Spencer, Marc van der Kamp

279

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1

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Biological and Medicinal Chemistry

Working Paper

An Efficient Computational Assay for β-Lactam Antibiotic Breakdown by Class A β-Lactamases

Viivi H. A. Hirvonen, Katharine Hammond, Ewa I. Chudyk, Michael A. L. Limb, James Spencer, Adrian Mulholland, Marc W. van der Kamp

446

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Organic Chemistry

Working Paper

Synthesis of Sulfoquinovose and Sulfoquinovosyl Diacylglycerides, and a Fluorogenic Substrate for Sulfoquinovosidases

Yunyang Zhang, Janice Mui, Thimali Arumaperuma, James P. Lingford, ETHAN GODDARD-BORGER, JONATHAN WHITE, Spencer Williams

544

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Biological and Medicinal Chemistry

Working Paper

Dynamic Structural Changes Accompany the Production of 2-Dihydroxypropanesulfonate by Sulfolactaldehyde Reductase

Mahima Sharma, Palika Abayakoon, James P. Lingford, Yi Jin, Ruwan Epa, Ethan D. Goddard-Borger, Gideon J. Davies, Spencer Williams

547

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Biological and Medicinal Chemistry

Working Paper

The Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis

Mahima Sharma, Palika Abayakoon, Ruwan Epa, Yi Jin, James P. Lingford, Tomohiro Shimada, Masahiro Nakano, Janice Mui, Akira Ishihama, Ethan D. Goddard-Borger, Gideon J. Davies, Spencer Williams

807

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1

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Catalysis

Working Paper

QM/MM Simulations Reveal the Determinants of Carbapenemase Activity in Class A β-lactamases

Ewa Chudyk, Michael Beer, Michael A.L. Limb, Charlotte A. Jones, James Spencer, Mark W. van der Kamp, Adrian Mulholland

256

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1

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Theoretical and Computational Chemistry

Working Paper

Evaluating scalable supervised learning for synthesize-on-demand chemical libraries

Moayad Alnammi, Shengchao Liu, Spencer S Ericksen, Gene E Ananiev, Andrew F Voter, Song Guo, James L Keck, F Michael Hoffmann, Scott A Wildman, Anthony Gitter

621

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Catalysis

Working Paper

Defining the molecular architecture, metal dependence, and distribution of metal-dependent class II sulfofructose-1-phosphate aldolases

Mahima Sharma, Arashdeep Kaur, Niccolay Madiedo Soler, James Lingford, Ruwan Epa, Ethan Goddard-Borger, Gideon Davies, Spencer Williams

98

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Refine Search

15 results in James Spencer in Authors: James Spencer

Small Changes in Hydration Determine Cephalosporinase Activity of OXA-48 β-Lactamases

Catalytic Mechanism of the Colistin Resistance Protein MCR-1

Multiscale simulations identify origins of differential carbapenem hydrolysis by the OXA-48 β-lactamase

An Efficient Computational Assay for β-Lactam Antibiotic Breakdown by Class A β-Lactamases

Synthesis of Sulfoquinovose and Sulfoquinovosyl Diacylglycerides, and a Fluorogenic Substrate for Sulfoquinovosidases

Dynamic Structural Changes Accompany the Production of 2-Dihydroxypropanesulfonate by Sulfolactaldehyde Reductase

The Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis

QM/MM Simulations Reveal the Determinants of Carbapenemase Activity in Class A β-lactamases

Evaluating scalable supervised learning for synthesize-on-demand chemical libraries

Defining the molecular architecture, metal dependence, and distribution of metal-dependent class II sulfofructose-1-phosphate aldolases

15 results in Authors: James Spencer