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Biological and Medicinal Chemistry

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Andrew Kruegel

2 results in Authors: Andrew Kruegel

Biological and Medicinal Chemistry

Site Selective C-H Functionalization of Mitragyna Alkaloids Reveals a Molecular Switch for Tuning Opioid Receptor Signaling Efficacy

Srijita Bhowmik, Juraj Galeta, Vaclav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Tomas Fiala, Amanda Hunkele, Andrew Kruegel, Susruta Majumdar, Jonathan A. Javitch,, Dalibor Sames

Version 1 posted 14 August 2020

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Biological and Medicinal Chemistry

7-Hydroxymitragynine is an Active Metabolite of Mitragynine and a Key Mediator of its Analgesic Effects

Andrew Kruegel, Rajendra Uprety, Steve Grinnell, Cory Langreck, Elizabeth Pekarskaya, Valerie Le Rouzic, Michael Ansonoff, Madalee M. Gassaway, John E. Pintar, Gavril W. Pasternak, Jonathan A. Javitch, Susruta Majumdar, Dalibor Sames

Version 1 posted 08 February 2019

1,563

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