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Electrophile Scanning Reveals Reactivity Hotspots for the Design of Covalent Peptide Binders

Nathalie M. Grob, Clint Remarcik, Simon L. Rössler, Jeffrey Y. K. Wong, John C. K. Wang, Jason Tao, Corey L. Smith, Andrei Loas, Stephen L. Buchwald, Dan L. Eaton, Magdalena Preciado López, Bradley L. Pentelute

Version 1 posted 19 June 2023

1,094

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1

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Organic Chemistry

Working Paper

Automated Fast-Flow Synthesis of Peptide Nucleic Acid Conjugates

Chengxi Li, Alexander J. Callahan, Kruttika-Suhas Phadke, Bryan Bellaire, Charlotte E. Farquhar, Genwei Zhang, Carly K. Schissel, Alexander J. Mijalis, Nina Hartrampf, Andrei Loas, David E. Verhoeven, Bradley Pentelute

Version 1 posted 24 February 2021

1,055

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Biological and Medicinal Chemistry

Working Paper

Reversibly reactive affinity selection mass spectrometry enables maturation of covalent peptides

Peiyuan Zhang, Xiyun Ye, John C.K. Wang, Hannah T. Baddock, Zena Jensvold, Ian Foe, Andrei Loas, Dan L. Eaton, Qi Hao, Aaron H. Nile, Bradley L. Pentelute

Version 1 posted 22 December 2023

462

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Theoretical and Computational Chemistry

Working Paper

Unsupervised machine learning leads to an abiotic picomolar peptide ligand

Joseph S. Brown, Somesh Mohapatra, Michael A. Lee, Roman Misteli, Yitong Tseo, Nathalie M. Grob, Anthony J. Quartararo, Andrei Loas, Rafael Gomez-Bombarelli, Bradley L. Pentelute

Version 1 posted 24 May 2023

900

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Organic Chemistry

Working Paper

Machine Learning Guides Peptide Nucleic Acid Flow Synthesis and Sequence Design

Chengxi Li, Genwei Zhang, Somesh Mohapatra, Alex Callahan, Andrei Loas, Rafael Gomez-Bombarelli, Bradley Pentelute

Version 1 posted 05 October 2021

749

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1

Citations

Organic Chemistry

Working Paper

Same Day Access to Proteins Enabled by Folding Selections

Alex J. Callahan, Aurélie Rondon, Lia Lozano Salazar, Satish Gandhesiri, Jacob Rodriguez, Andrei Loas, Bradley Pentelute

Version 1 posted 17 April 2023

435

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Organic Chemistry

Working Paper

Deep Learning for Prediction and Optimization of Fast-Flow Peptide Synthesis

Somesh Mohapatra, Nina Hartrampf, Mackenzie Poskus, Andrei Loas, Rafael Gomez-Bombarelli, Bradley L. Pentelute

Version 1 posted 14 July 2020

1,018

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Organic Chemistry

Working Paper

Automated Fast-Flow Synthesis of Antisense Phosphorodiamidate Morpholino Oligomers

Chengxi Li, Alexander J. Callahan, Mark D. Simon, Kyle A. Totaro, Alexander J. Mijalis, Nina Hartrampf, Carly K. Schissel, Ming Zhou, Hong Zong, Gunnar J. Hanson, Andrei Loas, Nicola L. B. Pohl, Bradley L. Pentelute

Version 1 posted 22 July 2020

895

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Organic Chemistry

Working Paper

Synthesis of Proteins by Automated Flow Chemistry

Nina Hartrampf, Azin Saebi, Mackenzie Poskus, Zachary P. Gates, Alexander J. Callahan, Amanda E. Cowfer, Stephanie Hanna, Sarah Antilla, Carly K. Schissel, Anthony J. Quartararo, Xiyun Ye, Alexander J. Mijalis, Mark D. Simon, Andrei Loas, Shunying Liu, Carsten Jessen, Thomas E. Nielsen, Bradley L. Pentelute

Version 1 posted 11 February 2020

2,714

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Biological and Medicinal Chemistry

Working Paper

Rapid Production of Native and Mirror-Image Tumor Necrosis Factor-α through the Synergy of Automated Flow Peptide Synthesis and Native Chemical Ligation

Ahmet Yesilcimen, Alex J. Callahan, Tara L. Travaline, Satish Gandhesiri, Olena S. Tokareva, Andrei Loas, John H. McGee, Bradley L. Pentelute

Version 1 posted 02 February 2024

304

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13 results in Andrei Loas in Authors: Andrei Loas

Electrophile Scanning Reveals Reactivity Hotspots for the Design of Covalent Peptide Binders

Automated Fast-Flow Synthesis of Peptide Nucleic Acid Conjugates

Reversibly reactive affinity selection mass spectrometry enables maturation of covalent peptides

Unsupervised machine learning leads to an abiotic picomolar peptide ligand

Machine Learning Guides Peptide Nucleic Acid Flow Synthesis and Sequence Design

Same Day Access to Proteins Enabled by Folding Selections

Deep Learning for Prediction and Optimization of Fast-Flow Peptide Synthesis

Automated Fast-Flow Synthesis of Antisense Phosphorodiamidate Morpholino Oligomers

Synthesis of Proteins by Automated Flow Chemistry

Rapid Production of Native and Mirror-Image Tumor Necrosis Factor-α through the Synergy of Automated Flow Peptide Synthesis and Native Chemical Ligation

13 results in Authors: Andrei Loas