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Discovery of de novo Macrocycle Inhibitors of Histone Deacetylase 11

Daniela Danková, Alexander Nielsen, Anna Zarda, Tobias Hansen, Marie Hesse, Michaela Benová, Athanasios Tsiris, Christian R. O. Bartling, Edward J. Will, Kristian Strømgaard, Carlos Moreno-Yruela, Christian Heinis, Christian Adam Olsen

Version 1 posted 09 December 2024

316

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Biological and Medicinal Chemistry

Working Paper

Irreversible Inhibition of BoNT/A Protease: Unique Warhead Reactivity and Function Contingent upon a Bifunctional Approach

Lewis Turner, Alexander Lund Nielsen, Lucy Lin, Sabine Pellett, Takashi Sugane, Margaret Olsen, Eric Johnson, Kim janda

Version 1 posted 20 January 2021

832

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Theoretical and Computational Chemistry

Working Paper

Autonomous Discovery of Materials for Intercalation Electrodes

Felix Tim Bölle, Nicolai Rask Mathiesen, Alexander Juul Nielsen, Tejs Vegge, Juan Maria García Lastra, Ivano E. Castelli

Version 1 posted 16 October 2019

722

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2

Citations

Organic Chemistry

Working Paper

Synthesis of Proteins by Automated Flow Chemistry

Nina Hartrampf, Azin Saebi, Mackenzie Poskus, Zachary P. Gates, Alexander J. Callahan, Amanda E. Cowfer, Stephanie Hanna, Sarah Antilla, Carly K. Schissel, Anthony J. Quartararo, Xiyun Ye, Alexander J. Mijalis, Mark D. Simon, Andrei Loas, Shunying Liu, Carsten Jessen, Thomas E. Nielsen, Bradley L. Pentelute

Version 1 posted 11 February 2020

2,863

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Biological and Medicinal Chemistry

Working Paper

Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease

Lewis Turner, Alexander Lund Nielsen, Lucy Lin, Antonio J. Campedelli, Nicholas Silvaggi, Jason Chen, Amanda E. Wakefield, Karen N. Allen, Kim janda

Version 1 posted 08 June 2021

310

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Biological and Medicinal Chemistry

Working Paper

Dethioacylation by Sirtuins 1–3: Considerations for Drug Design using Mechanism-based Sirtuin Inhibition

Nima Rajabi, Alexander Lund Nielsen, Christian Adam Olsen

Version 2 posted 03 February 2020

1,043

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Catalysis

Working Paper

Ru-nitrosyl complex salts as efficient catalysts for the reversible CO2 hydrogenation/FA dehydrogenation in ionic liquids

José Tiago Menezes Correia, Valeria Nori, Mike Steffen Bernhard Jørgensen, Alexander Tobias Nikol, Martin Nielsen

Version 1 posted 15 November 2024

107

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Biological and Medicinal Chemistry

Working Paper

Mitochondria-Targeted Inhibitors of the Human SIRT3 Lysine Deacetylase

Kathrin Sten Troelsen, Michael Bæk,, Alexander Lund Nielsen, Andreas Stahl Madasen, Nima Rajabi, Christian Adam Olsen

Version 2 posted 27 November 2020

820

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Biological and Medicinal Chemistry

Working Paper

Investigation of Carboxylic Acid Isosteres for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

Nima Rajabi, Alexander L. Nielsen, Tobias N. Hansen, Huy T. Nguyen, Michael Bæk, Julie E. Bolding, Oskar Ø. Bahlke, Sylvester E. G. Petersen, Christian R. O. Bartling, Kristian Strømgaard, Christian Adam Olsen

Version 1 posted 24 November 2021

402

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9 results in Alexander Nielsen in Authors: Alexander Nielsen

Discovery of de novo Macrocycle Inhibitors of Histone Deacetylase 11

Irreversible Inhibition of BoNT/A Protease: Unique Warhead Reactivity and Function Contingent upon a Bifunctional Approach

Autonomous Discovery of Materials for Intercalation Electrodes

Synthesis of Proteins by Automated Flow Chemistry

Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease

Dethioacylation by Sirtuins 1–3: Considerations for Drug Design using Mechanism-based Sirtuin Inhibition

Ru-nitrosyl complex salts as efficient catalysts for the reversible CO2 hydrogenation/FA dehydrogenation in ionic liquids

Mitochondria-Targeted Inhibitors of the Human SIRT3 Lysine Deacetylase

Investigation of Carboxylic Acid Isosteres for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

9 results in Authors: Alexander Nielsen