Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Deriving the Isoelectric Point of Amino Acids from Acid-Base Equilibria

10 January 2025, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This paper presents a refined method for calculating the isoelectric point (pI) of amino acids, focusing on the dominant zwitterionic form in solution. The approach improves pI calculations and extends to predicting pH values in amphoteric solutions, including titrations of polyprotic acids and bases.

Keywords

Isoelectric point
Acid-base equillibia
Zwitterion
Amphoteric species
Thermodynamics
Kinetics

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Jan 10, 2025 Version 1

Metrics

2,348
44
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2025-9tpw3
D O I: 10.26434/chemrxiv-2025-9tpw3 [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Share