Reactions of cold argon plasmas with condensed-phase peptides and proteins for mass spectrometry imaging and structural eluci-dation

21 August 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The analysis of macromolecules - such as proteins - pose a significant bottleneck in analytical science. We have developed surface treatment techniques utilising direct and radiofrequency current argon plasmas, able to quickly digest condensed-phase macromolecules while maintaining spatial resolution of analytes. We show here that these plasmas can be powerful tools for mass spectrometry imaging of peptides and proteins.

Keywords

Plasma
Mass Spectrometry Imaging
Spatial Resolution
Proteomics
Peptidomics
Macromolecules

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