Abstract
This review explores the substantial progress in metabolomics and its essential role in deciphering plant-microbe interactions. It details how metabolomics has revealed the metabolic changes during pathogen attacks, pinpointed crucial metabolites associated with plant resistance, and supported the breeding of crops with improved disease resistance. Additionally, the review examines the metabolic intricacies of symbiotic relationships, emphasizing the significance of signaling metabolites, and highlights the discovery of bioactive compounds from endophytes with potential agricultural and biotechnological applications. By synthesizing recent research, this review provides an in-depth view of how metabolomics has transformed our comprehension of the complex chemical interactions between plants and their microbial partners, promoting the development of more sustainable and resilient agricultural practices.