Modern Electrospray Ionization Mass Spectrometry Techniques for the Characterisation of Supramolecules and Coordination Compounds

08 April 2024, Version 2
This content is a preprint and has not undergone peer review at the time of posting.


Mass spectrometry is routinely used for myriad applications in clinical, industrial, and research laboratories worldwide. Developments in the areas of ionisation sources, high-resolution mass analysers, tandem mass spectrometry, and ion mobility have significantly extended the repertoire of mass spectrometrists, however for coordination compounds and supramolecules, mass spectrometry remains underexplored and arguably underappreciated. Here, the reader is guided through different tools of modern electrospray ionization mass spectrometry that are suitable for larger inorganic complexes. All steps, from sample preparation and technical details to data analysis and interpretation are discussed. The main target audience of this tutorial are synthetic chemists as well as technicians/mass spectrometrists with little experience in characterising labile inorganic compounds.


Mass Spectrometry
Coordination Compounds
Sample Preparation
Technical Details
Ion Transfer
Mass Spectra Analysis

Supplementary materials

Supplementary Information
MS data for the example of the ternary complex involving Z2; Case example for the characterisation of the heterometallic rotaxane AmMn using different MS methods


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