HPLC Training for All: Integration of Multi-Language Artificial Intelligence (AI) Avatars in Virtual Reality (VR) Digital Twin Laboratories

08 April 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


The integration of High-Performance Liquid Chromatography (HPLC) training into academic curricula remains a challenge, due to the complexities of its theoretical concepts and the cost-prohibitive nature of HPLC instrumentation. This challenge in training is further compounded for students who are taught in the English language and for whom English is a Foreign Language (EFL), and who may struggle to understand traditional learning materials. This paper introduces a pioneering Virtual Reality (VR) platform for immersive HPLC training that is coupled with a conversationally intelligent Artificial Intelligence (AI) avatar capable of multilingual support. This approach provides students with an on-hand tutor for adaptive, immersive learning practices in whatever language they feel comfortable speaking in. The effectiveness of the AI models were evaluated via a survey of postgraduate Chemistry students at UCL, and the responses were analysed computationally using a series of evaluation metrics. Evaluation from TF-IDF, BLEU and BERT statistical analysis demonstrated that the AI avatar had superior linguistic and instructional performance across English, Spanish, and German, particularly in complex concept explanations, validating the potential for multilingual AI support in education. Survey feedback revealed that the AI Avatars with a knowledge bank significantly improved HPLC learning outcomes, with participants rating their engagement and the quality of learning above traditional methods.


Virtual Reality
artificial intelligence


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.