Gold Mono and Bis N-Heterocyclic Carbenes based on mRNA cap0

Eukaryotic mRNA contains a cap structure which consists of a methylated guanosine (mRNA cap0) connected to the first transcribed nucleotide by an unusual 5′-5′-triphosphate bridge. Herein we describe the synthesis gold mono and bis-N-Heterocyclic carbenes derived from 7-methylguanosine at room temperature. The compounds can be synthesized directly from 7-methylguanosine and the synthesis does not require the protection of the hydroxyl groups pf the ribose to be effective.