Gold Mono and Bis N-Heterocyclic Carbenes based on mRNA cap0

08 March 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Eukaryotic mRNA contains a cap structure which consists of a methylated guanosine (mRNA cap0) connected to the first transcribed nucleotide by an unusual 5′-5′-triphosphate bridge. Herein we describe the synthesis gold mono and bis-N-Heterocyclic carbenes derived from 7-methylguanosine at room temperature. The compounds can be synthesized directly from 7-methylguanosine and the synthesis does not require the protection of the hydroxyl groups pf the ribose to be effective.

Keywords

mRNA cap0 • 7-methylguanosine • N-Heterocyclic carbenes • Gold(I)

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