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Abstract
Six undescribed cephalotane-type diterpenoids and/or norditerpenoids, ceforloids A–F (1–6), were isolated from Cephalotaxus fortunei var. alpina and C. sinensis. Their structures were elucidated by comprehensive analysis of spectroscopic data. Compound 1 possesses an unprecedented norditerpenoid skeleton featuring an unusual acetophenone moiety, and originated putatively from a disparate biogenetic pathway. Compounds 4 and 5 incorporate a unique 12,13-p-hydroxybenzylidene acetal motif. Compound 6 is a rare cephalotane-type diterpenoid glycoside. Immunosuppressive assays showed that compounds 2 and 6 exhibited mild suppressive activity against the activated T and B lymphocytes proliferation.
Supplementary materials
Title
Supporting Information
Description
IR, MS, NMR, and ECD spectra of compounds 1-7; key 2D NMR correlations of compounds 2, 3, 5 and 7; and computational details for compounds 2 and 3 (PDF)
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