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Highly Oxygenated Cephalotane-Type Diterpenoids from Cephalotaxus fortunei var. alpina and C. sinensis

06 November 2023, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Six new highly oxygenated cephalotane-type diterpenoids and/or norditerpenoids, ceforloids A–F (1–6), were isolated and characterized by comprehensive analysis of spectroscopic data. Compound 1 possesses a new norditerpenoid skeleton featuring an unusual acetophenone moiety, and originated putatively via an entirely disparate biogenetic pathway. Compounds 4 and 5 incorporate a unique 12,13-p-hydroxybenzylidene acetal motif. Compound 6 represents the second cephalotane-type diterpenoid glycoside, showing moderate immunosuppressive activity against T lymphocyte cells with an IC50 value of 1.93 μM and good selectivity (SI = 22.8).

Keywords

cephalotane
ceforloid
diterpenoid
immunosuppressive
Cephalotaxus

Supplementary materials

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Description
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Supporting Information
Description
IR, MS, NMR, and ECD spectra of compounds 1-7; key 2D NMR correlations of compounds 2, 3, 5 and 7; and computational details for compounds 2 and 3 (PDF)
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Version History

Nov 06, 2023 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2023-8v6dr
D O I: 10.26434/chemrxiv-2023-8v6dr [opens in a new tab]

Funding

National Natural Science Foundation of China
22237007, T2192972
Youth Innovation Promotion Association of the Chinese Academy of Sciences
2022282, 2023293
Biological Resources Program of Chinese Academy of Sciences
KFJ-BRP-008-001

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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