A Visible Light Driven Direct synthesis of Industrially Relevant Glutaric Acid Diesters from Aldehydes

Alpha-substituted glutaric diesters are synthesized directly from acrylates and aldehydes under visible light. This process provides a direct access to alpha-substituted glutaric diesters by exploring the HAT property of Eosin Y followed by the consecutive Giese type addition. We have performed the reaction under sunlight as a sustainable alternative light source. As an application of this protocol, the biologically potent and industrially relevant substituted 4,5-dihydro-2H-pyridazinones have also been directly synthesized from alpha-substituted glutaric diesters. A detailed and systematic control experiments have been carried out to investigate the plausible mechanistic pathway.