Abstract
A direct access to a-substituted glutaric diesters from acrylates and aldehydes by exploring the HAT property of Eosin Y followed by consecutive Giese type addition to construct substituted glutaric diesters. The practicality of the protocol has been demonstrated with a wide range of substrate scope. We have also successfully performed the transformation under direct exposure of natural sunlight as a light source to achieve the sustainability. As an application of this protocol, the biologically potent and industrially relevant substituted 4,5-dihydro-2H pyridazinones have also been directly synthesized from substituted glutaric diesters. A detailed and systematic control experiments have been carried out to investigate the plausible mechanistic pathway.
Supplementary materials
Title
A Visible Light Driven Direct synthesis of Industrially Relevant Glutaric Acid Diesters from Aldehydes
Description
The supporting information includes general experimental procedures, details of control experiments, compound characterisation data and copies of proton and carbon spectra.
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