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Abstract
Resin 3D printing is attractive for fabrication of microscale cell-culture devices, but common resin materials are unstable and toxic under cell culture conditions or extended periods of fluid flow. Here, we evaluated the effectiveness of using parylene-C coating of commercially available clear resins to prevent cytotoxic leaching, degradation of microfluidic devices, and absorption of small molecules. We found that parylene-C significantly improved both the cytocompatibility with primary white blood cell cultures and the material integrity of prints, while maintaining the favorable optical qualities held by clear resins.
Supplementary materials
Title
Electronic Supplementary Materials
Description
Supplementary materials including the following:
• Design files: Link to access 3D printed files used in the main text (Figure 1a-c)
• Supplemental Figure S1: Combined transparency data for three commercial resins, uncoated and parylene-coated.
• Supplemental Figure S2: Combined autofluorescence data for three commercial resins, uncoated and parylene-coated.
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