Digitisation of a Modular Plug and Play 3D Printed Continuous Flow System for Chemical Synthesis

We describe the development of a digital modular 3D printed continuous flow system to carry out both classical and photochemical synthesis that uses a novel PC based software interface. Using this system, we describe how we were able to both control and monitor reaction conditions at the same time. The system integrates in-line sensors via a simple cassette based system that is analogous to a games console enabling hot-swopping of modules by a user. To control the system, an PC-interface platform was created to automate the control of the system functionality, as well as the reporting of sensor parameters. The utility of the system was demonstrated by performing a series of reactions highlighting the importance that precise control of solvent flow rate and accurate reporting of reaction temperatures can have on standardization and reproducibility and that the system can be easily modified to allow for scale-up synthesis.