A Fully Biocatalytic Approach to Angiopterlactone B Based on a Chemoinspired Artificial in Vitro Metabolism

23 January 2023, Version 2
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Nature's way to construct highly complex molecular entities with virtue as part of biosynthetic pathways is unmatched by any chemical synthesis. Yet, relying on a cascade of native enzymatic transformations to achieve a certain target structure, biosynthesis is also significantly limited in its scope. In this work, non-natural biocatalytic modules are successfully implemented into an artificial metabolism, combining the benefits of traditional retrosynthesis with the elegance and efficacy of biosynthetic networks. In a highly streamlined process, a total synthesis of the tricyclic angiopterlactone B is achieved operating entirely in an aqueous environment while relying on enzymes as reaction mediators.

Keywords

artificial metabolism
biocatalysis
cascade design
natural product synthesis
angiopterlactone

Supplementary materials

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Supplementary materials
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Experimental protocols, spectroscopic and chromatographic data
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