A Fully Biocatalytic Approach to Angiopterlactone B Based on a Chemoinspired Artificial in Vitro Metabolism

Abstract

<p>Nature's way to construct highly complex molecular entities with virtue as part of biosynthetic pathways is unmatched by any chemical synthesis. Yet, relying on a cascade of native enzymatic transformations to achieve a certain target structure, biosynthesis is also significantly limited in its scope. In this work, non-natural biocatalytic modules are successfully implemented into an artificial metabolism, combining the benefits of traditional retrosynthesis with the elegance and efficacy of biosynthetic networks. In a highly streamlined process, a total synthesis of the tricyclic angiopterlactone B is achieved operating entirely in an aqueous environment while relying on enzymes as reaction mediators.</p>

Version notes

The main article was shorted to be more directly addressing the target molecule synthesis, while secondary observations were moved to the supplementary material.

Content

Supplementary material

Supplementary materials
Experimental protocols, spectroscopic and chromatographic data