A Fully Biocatalytic Approach to Angiopterlactone B Based on a Chemoinspired Artificial in Vitro Metabolism

27 May 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Nature's way to construct highly complex molecular entities with virtue as part of biosynthetic pathways is unmatched by any chemical synthesis. Yet, relying on a cascade of native enzymatic transformations to achieve a certain target structure, biosynthesis is also significantly limited in its scope. In this work, non-natural biocatalytic modules are successfully implemented into an artificial metabolism, combining the benefits of traditional retrosynthesis with the elegance and efficacy of biosynthetic networks. In a highly streamlined process, a fully enzymatic total synthesis of the tricyclic angiopterlactone B is achieved.


Enzyme cascades
Total Synthesis
Asymmetric Catalysis
Synthetic biology


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