Self-Adapting Graphitic C6N6-Based Copper Single-Atom Catalyst for Smart Biosensors

05 December 2022, Version 2
This content is a preprint and has not undergone peer review at the time of posting.


Self-adaptability is highly envisioned for artificial devices such as robots with chemical noses. For this goal, seeking catalysts with multiple and modulable reaction pathways is promising but generally hampered by inconsistent reaction conditions. Herein, we report a self-adaptive CuSAC6N6 single-atom catalyst having two reactive oxygen-oriented pathways under the same reaction conditions. CuSAC6N6 consisted of coordinated peroxidase-like Cu-N coordination centers and photo-responsive donor-π-acceptor (D-π-A) units with promoted intramolecular charge separation and migration. Interestingly, it drove the basic oxidation of peroxidase substrates by the bound copper-oxo pathway, and undertook a second gain reaction triggered by light via the free hydroxyl radical pathway under the same conditions. A remarkable basic activity and a superb gain of up to 3.6 times under household lights were observed, significantly higher than that of its control systems, including solo carbon nitride-based nanozymes or photocatalysts, their mixtures, and even that under thermal stimuli to the maximum endured temperature for most lives. As an application, the self-adapting CuSAC6N6 was used to construct a glucose biosensor, which can intelligently switch the linear detection range and sensitivity to a diverse range of concentrations in vitro.


carbon nitride
single atom catalysts
smart biosensors

Supplementary materials

Supporting information
Detailed experimental, more figures, tables, discussions, and references.


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.