Light-fuelled dissipative replication and selection in evolvable biomimetic chemical networks

05 May 2022, Version 3
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The concept of chemically evolvable replicators is central to abiogenesis. Evolvability requires three essential components: energy harvesting mechanisms for non-equilibrium dissipation, effective decomposition pathways and transfer of structural information in the autocatalytic cycles. We observed a UVA light-fuelled dissipative chemical network displaying sequence-dependent replication and replicator decomposition. The system was constructed with primitive peptidic foldamer components. The photocatalytic formation-recombination cycle of thiyl radicals was coupled with the molecular recognition steps in the replication cycles. Thiyl radical-mediated chain reaction was responsible for the replicator death mechanism. The competing and kinetically asymmetric replication and decomposition processes led to light intensity-dependent selection far from equilibrium. Here we show that this system can dynamically adapt to the level of energy influx and seeding. The results highlight the feasibility of the complex phenomenon of chemical evolvability with primitive building blocks and simple chemical reactions.

Keywords

dissipative adaptation
replication
chemical evolution
foldamer
disulphide
systems chemistry
dissipative assembly
non-equilibrium thermodynamics

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