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Fluoro-bicyclo[1.1.1]pentanes

29 April 2022, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

After more than 20 years of trials, a practical scalable approach to fluoro-bicyclo[1.1.1]pentanes (19F-BCPs) has been developed. Physico-chemical properties of fluoro-bicyclo[1.1.1]pentanes have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen instead of the fluorophenyl ring.

Keywords

bicyclo[1.1.1]pentane
fluorine
BCP
bioisostere
medicinal chemistry

Supplementary materials

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Version History

Apr 29, 2022 Version 1

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The content is available under CC BY NC 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-8b85l
D O I: 10.26434/chemrxiv-2022-8b85l [opens in a new tab]

Funding

European Research Council
101000893 - BENOVELTY

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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